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- W2051212130 abstract "Summary Background: The direct factor Xa inhibitor rivaroxaban is approved for venous throm-boembolism (VTE) treatment in adults. However, in all phase-III trials children or adolescents have not been included. For under-aged VTE patients, current standard treatment consists of low molecular weight heparin or Vitamin K antagonists. Rivaroxaban could be an attractive alternative, however, no data on the pharmacokinetics (PK) of rivaroxaban in adolescents are currently available. Patient, methods: We report PK data for rivaroxaban derived from a girl (age:15 years), who presented three month after acute deep vein thrombosis, already receiving rivaroxaban therapy. In the steady state of rivaroxaban therapy (20 mg once daily), plasma levels at baseline, 3 and 6 hours after intake of rivaroxaban were measured to evaluate the pharmacokinetics and changes of global coagulation tests. Results: At baseline, a very low trough level of only 9.9 ng/ml rivaroxaban was found. At 3 hours, a peak concentration of 137.76 ng/ml rivaroxaban was observed with a rapid decrease within 6 hours after drug intake, when plasma levels of 34.45 ng/ml were measured. The patients INR and aPTT values reacted correspondingly. Conclusion: Our data indicate that adolescents may exhibit lower peak and trough levels after rivaroxaban intake compared to adult patients, but seem to have similar PK curves during the elimination phase. While our case is the first published case of a successful VTE treatment in an under-aged , we strongly discourage the routine use of rivaroxaban in non-adult patients, until data from phase II and III trials are available." @default.
- W2051212130 created "2016-06-24" @default.
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- W2051212130 date "2014-01-01" @default.
- W2051212130 modified "2023-10-06" @default.
- W2051212130 title "Phamacokinetics of rivaroxaban in adolescents" @default.
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- W2051212130 doi "https://doi.org/10.5482/hamo-13-06-0033" @default.
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