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• W2051213196 abstract "The effect of nitric oxide (NO) on osteoblastic differentiation was examined in cultured mouse osteoblasts. Interleukin-1beta and tumor necrosis factor-alpha expressed inducible NO synthase gene with little effect on constitutive NO synthase gene. These cytokines increased NO production, which was inhibited by L-NMMA pretreatment, and decreased alkaline phosphatase (AIPase) activity, which was not restored by L-NMMA. Furthermore, NO donors, sodium nitroprusside and NONOate dose-dependently elevated AIPase activity and expression of osteocalcin gene. These results suggest that NO directly facilitates osteoblastic differentiation and the cytokine-induced inhibition of AIPase activity is mediated via mechanism other than NO." @default.
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• W2051213196 date "1997-06-30" @default.
• W2051213196 modified "2023-10-09" @default.
• W2051213196 title "Direct action of nitric oxide on osteoblastic differentiation" @default.
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• W2051213196 doi "https://doi.org/10.1016/s0014-5793(97)00597-8" @default.
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