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- W2051213237 abstract "The purpose of this study was to validate DCE-MRI parameters such as blood flow (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mi>F</mml:mi></mml:mrow></mml:math>), permeability surface area product (PS), fractional intravascular space (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:msub><mml:mi>v</mml:mi><mml:mn>1</mml:mn></mml:msub></mml:mrow></mml:math>), and fractional extracellular extravascular space (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mrow><mml:msub><mml:mi>v</mml:mi><mml:mn>2</mml:mn></mml:msub></mml:mrow></mml:math>), obtained using a standard two-compartment model against other established analysis methods and histological indices. DCE-MRI datasets of 28 mice implanted with various human cancer xenografts were acquired and analyzed. Statistically significant correlations were found between the parameters derived from the standard two-compartment model (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mrow><mml:msub><mml:mi>v</mml:mi><mml:mn>1</mml:mn></mml:msub></mml:mrow></mml:math>, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mrow><mml:msub><mml:mi>v</mml:mi><mml:mn>2</mml:mn></mml:msub></mml:mrow></mml:math>, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mrow><mml:mi>F</mml:mi></mml:mrow></mml:math>, and PS) with the histological markers of intravascular and interstitial space and with the corresponding flow and permeability estimates obtained by the initial slope method and Patlak plot, respectively." @default.
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- W2051213237 date "2015-02-16" @default.
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- W2051213237 title "Validation of Microcirculatory Parameters Derived from the Standard Two-Compartment Model with Murine Xenografts Model" @default.
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- W2051213237 doi "https://doi.org/10.1155/2015/769849" @default.
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