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- W2051213562 abstract "The human genome comprises large chromosomes in the nucleus and mitochondrial DNA (mtDNA) housed in the dynamic mitochondrial network. Human cells contain up to thousands of copies of the double-stranded, circular mtDNA molecule that encodes essential subunits of the oxidative phosphorylation complexes and the rRNAs and tRNAs needed to translate these in the organelle matrix. Transcription of human mtDNA is directed by a single-subunit RNA polymerase, POLRMT, which requires two primary transcription factors, TFB2M (transcription factor B2, mitochondrial) and TFAM (transcription factor A, mitochondrial), to achieve basal regulation of the system. Here, we review recent advances in understanding the structure and function of the primary human transcription machinery and the other factors that facilitate steps in transcription beyond initiation and provide more intricate control over the system." @default.
- W2051213562 created "2016-06-24" @default.
- W2051213562 creator A5079476247 @default.
- W2051213562 creator A5082064073 @default.
- W2051213562 date "2013-06-01" @default.
- W2051213562 modified "2023-09-26" @default.
- W2051213562 title "Accessorizing the human mitochondrial transcription machinery" @default.
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- W2051213562 doi "https://doi.org/10.1016/j.tibs.2013.03.006" @default.
- W2051213562 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3698603" @default.
- W2051213562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23632312" @default.
- W2051213562 hasPublicationYear "2013" @default.
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