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• W2051214236 abstract "Rationale: Macrophage migration inhibitory factor (MIF) is a key proinflammatory mediator. It contributes toward an exaggerated gram-negative inflammatory response via its ability to induce Toll-like receptor–4 expression. Studies have shown that MIF knockout mice have less aggressive Pseudomonas infection (compared with wild-type).Objectives: To assess whether a novel functional MIF polymorphism was associated with clinical prognosis in a patient cohort with chronic gram-negative infection, namely cystic fibrosis (CF).Methods: Collected genomic DNA was analyzed via polymerase chain reaction amplification for the polymorphic region for the CATT repeat polymorphism. Individuals may have a 5-, 6-, 7-, or 8-CATT tetranucleotide repeat unit on each allele. The 5-CATT repeat allele exhibits the lowest MIF promoter activity.Measurements and Main Results: Patients with stable CF (n = 167) and a matched control group (n = 166) were enrolled. In patients with CF, the MIF5+ group had a decreased incidence of Pseudomonas aeruginosa colonization (odds ratio, 0.25; 95% confidence interval, 0.09–0.65; p = 0.004) and a significant reduction in the risk of pancreatic insufficiency (odds ratio, 0.27; 95% confidence interval, 0.07–1.0; p = 0.05). A trend toward milder disease activity in the MIF5+ group was seen with all other parameters.Conclusions: The results support the concept of a regulatory role for MIF in CF." @default.
• W2051214236 created "2016-06-24" @default.
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• W2051214236 date "2005-12-01" @default.
• W2051214236 modified "2023-10-14" @default.
• W2051214236 title "Cystic Fibrosis, Disease Severity, and a Macrophage Migration Inhibitory Factor Polymorphism" @default.
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• W2051214236 doi "https://doi.org/10.1164/rccm.200412-1714oc" @default.
• W2051214236 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16179637" @default.
• W2051214236 hasPublicationYear "2005" @default.
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