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• W2051214439 abstract "Micacocidin is a promising natural product for the treatment of Mycoplasma pneumoniae infections. In the biosynthesis of this antibiotic, a fatty acid-AMP ligase (FAAL) activates the starter unit hexanoic acid as acyl-adenylate and forwards it to an iteratively acting polyketide synthase. Biochemical analysis of the FAAL revealed an extended substrate tolerance, thereby opening the door for the modification of a micacocidin residue that is barely accessible via semisynthesis. A total of six new analogues were generated by precursor-directed biosynthesis in this study and profiled against M. pneumoniae." @default.
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• W2051214439 date "2014-01-01" @default.
• W2051214439 modified "2023-09-25" @default.
• W2051214439 title "Precursor-directed biosynthesis of micacocidin derivatives with activity against Mycoplasma pneumoniae" @default.
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• W2051214439 doi "https://doi.org/10.1039/c3ob41839a" @default.
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