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• W2051214933 endingPage "e102843" @default.
• W2051214933 startingPage "e102843" @default.
• W2051214933 abstract "Islet alpha- and delta-cells are spared autoimmune destruction directed at beta-cells in type 1 diabetes resulting in an apparent increase of non-beta endocrine cells in the islet core. We determined how islet remodeling in autoimmune diabetes compares to streptozotocin (STZ)-induced diabetes. Islet cell mass, proliferation, and immune cell infiltration in pancreas sections from diabetic NOD mice and mice with STZ-induced diabetes was assessed using quantitative image analysis. Serial sections were stained for various beta-cell markers and Ngn3, typically restricted to embryonic tissue, was only upregulated in diabetic NOD mouse islets. Serum levels of insulin, glucagon and GLP-1 were measured to compare hormone levels with respect to disease state. Total pancreatic alpha-cell mass did not change as autoimmune diabetes developed in NOD mice despite the proportion of islet area comprised of alpha- and delta-cells increased. By contrast, alpha- and delta-cell mass was increased in mice with STZ-induced diabetes. Serum levels of glucagon reflected these changes in alpha-cell mass: glucagon levels remained constant in NOD mice over time but increased significantly in STZ-induced diabetes. Increased serum GLP-1 levels were found in both models of diabetes, likely due to alpha-cell expression of prohormone convertase 1/3. Alpha- or delta-cell mass in STZ-diabetic mice did not normalize by replacement of insulin via osmotic mini-pumps or islet transplantation. Hence, the inflammatory milieu in NOD mouse islets may restrict alpha-cell expansion highlighting important differences between these two diabetes models and raising the possibility that increased alpha-cell mass might contribute to the hyperglycemia observed in the STZ model." @default.
• W2051214933 created "2016-06-24" @default.
• W2051214933 creator A5025257244 @default.
• W2051214933 creator A5057478287 @default.
• W2051214933 creator A5061469419 @default.
• W2051214933 date "2014-08-07" @default.
• W2051214933 modified "2023-10-16" @default.
• W2051214933 title "Islet Remodeling in Female Mice with Spontaneous Autoimmune and Streptozotocin-Induced Diabetes" @default.
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• W2051214933 doi "https://doi.org/10.1371/journal.pone.0102843" @default.
• W2051214933 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4125302" @default.
• W2051214933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25101835" @default.
• W2051214933 hasPublicationYear "2014" @default.
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