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• W2051215061 endingPage "1007" @default.
• W2051215061 startingPage "999" @default.
• W2051215061 abstract "Massive striatal dopamine release during cerebral ischaemia has been implicated in the resulting neuronal damage. Sodium influx is an early event in the biochemical cascade during ischaemia and blockade of sodium channels may increase resistance to ischaemia by reducing energy demand involved in compensation for sodium and potassium fluxes. In this study, we have determined the effects of opening and blockade of voltage-gated sodium channels on hypoxia/hypoglycaemia-induced dopamine release. Slices of rat caudate nucleus were maintained in a slice chamber superfused by an oxygenated artificial cerebrospinal fluid containing 4 mM glucose. Ischaemia (hypoxia/hypoglycaemia) was mimicked by a switch to a deoxygenated artificial cerebrospinal fluid containing 2 mM glucose and dopamine release was measured using fast cyclic voltammetry. In drug-free (control) slices, there was a 2–3 min delay after the onset of hypoxia/hypoglycaemia followed by a rapid dopamine release event which was associated with anoxic depolarization. In slices treated with the Na+ channel opener, veratridine (1 μM), the time to onset of dopamine release was shortened (101±20 s, compared with 171±8 s in controls, P<0.05). Conversely, phenytoin (100 μM), lignocaine (200 μM) and the highly selective sodium channel blocker, tetrodotoxin (1 μM) markedly delayed and slowed dopamine release vs paired controls. In the majority of cases, dopamine release was biphasic after sodium channel blockade: a slow phase preceded a more rapid dopamine release event. The latter was associated with anoxic depolarization. Neither the fast nor the slow release events were affected by pretreatment with the selective dopamine uptake blocker GBR12935 (0.2 μM), suggesting that uptake carrier reversal did not contribute to these events. In conclusion, sodium channel antagonism delays and slows hypoxia/hypoglycaemia-induced dopamine release in vitro. Furthermore, sodium channel blockade delays anoxic depolarization and its associated neurotransmitter release, revealing an earlier dopamine release event that does not result from reversal of the uptake carrier." @default.
• W2051215061 created "2016-06-24" @default.
• W2051215061 creator A5012790326 @default.
• W2051215061 creator A5042186518 @default.
• W2051215061 date "1997-10-01" @default.
• W2051215061 modified "2023-10-10" @default.
• W2051215061 title "Sodium channel blockade unmasks two temporally distinct mechanisms of striatal dopamine release during hypoxia/hypoglycaemia in vitro" @default.
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• W2051215061 doi "https://doi.org/10.1016/s0306-4522(97)00259-5" @default.
• W2051215061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9330362" @default.
• W2051215061 hasPublicationYear "1997" @default.
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