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• W2051215268 abstract "Differentiation of murine 3T3-L1 preadipocytes into adipocytes is associated with the acquisition of apoptotic resistance accompanied by the upregulation of cell survival genes. We have now examined the effect of adipogenesis on apoptotic susceptibility of human abdominal preadipocytes in primary culture. To induce apoptosis, human preadipocytes, or their differentiated counterparts, were serum-deprived for 24 or 48 hours. When indicated, ceramide was also used as an apoptotic trigger. Cell death was assessed by enumeration of adherent viable cells, and its apoptotic nature was verified by Hoechst staining and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL). After 48 hours of serum withdrawal, cell death was 26% ± 4% in preadipocytes and was increased to 41% ± 4% in differentiated adipocytes (mean ± SE; n = 7 patients; P < .002). Under serum-free conditions for 24 hours, ceramide-induced cell death was 40% ± 6% in preadipocytes and increased to 68% ± 8% in adipocytes (mean ± SE; P < .01; n = 8 patients). Neuronal apoptosis inhibitor protein (NAIP), an antiapoptotic protein cell survival that increases upon 3T3-L1 adipogenesis, was reduced in human preadipocytes undergoing differentiation (n = 6 patients). Preadipocytes derived from omental versus subcutaneous abdominal fat were more susceptible to apoptosis induced by serum deprivation, 16% ± 4% versus 31% ± 3% cell death, respectively (mean ± SE; P < .02; n = 7 patients). Although the murine 3T3-L1 preadipocyte cell line is a useful model that approximates primary preadipocyte cell biology, our data derived from human preadipocyte studies suggest important differences with respect to the regulation of apoptosis." @default.
• W2051215268 created "2016-06-24" @default.
• W2051215268 creator A5059049451 @default.
• W2051215268 creator A5080610661 @default.
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• W2051215268 date "2003-08-01" @default.
• W2051215268 modified "2023-10-12" @default.
• W2051215268 title "Apoptosis of human abdominal preadipocytes before and after differentiation into adipocytes in culture" @default.
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• W2051215268 doi "https://doi.org/10.1016/s0026-0495(03)00165-3" @default.
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