Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051215273> ?p ?o ?g. }
- W2051215273 endingPage "327" @default.
- W2051215273 startingPage "323" @default.
- W2051215273 abstract "Leishmania infantum nicotinamidase, encoded by the Lipnc1 gene, converts nicotinamide into nicotinic acid to ensure Nicotinamide–Adenine–Dinucleotide (NAD+) biosynthesis. We were curious to explore the role of this enzyme during L. infantum development in its natural sand fly vector, Phlebotomus perniciosus (Diptera, Phlebotominae), using null mutants with a deleted Lipnc1 gene. The null mutants developed as well as the wild type L. infantum at the early time points post their ingestion within the blood meal. In contrast, once the blood meal digestion was completed, the null mutants were unable to develop further and establish late-stage infections. Data highlight the importance of the nicotinamide degradation pathway for Leishmania development in sand flies. They indicate that the endogenous nicotinamidase is essential for Leishmania development in the sand fly after the blood meal has been digested and the remnants defecated." @default.
- W2051215273 created "2016-06-24" @default.
- W2051215273 creator A5007413802 @default.
- W2051215273 creator A5013936064 @default.
- W2051215273 creator A5014200764 @default.
- W2051215273 creator A5020308293 @default.
- W2051215273 creator A5036161938 @default.
- W2051215273 creator A5049388262 @default.
- W2051215273 creator A5091678548 @default.
- W2051215273 date "2012-04-01" @default.
- W2051215273 modified "2023-10-18" @default.
- W2051215273 title "Leishmania infantum nicotinamidase is required for late-stage development in its natural sand fly vector, Phlebotomus perniciosus" @default.
- W2051215273 cites W1559018846 @default.
- W2051215273 cites W1837933631 @default.
- W2051215273 cites W1977433737 @default.
- W2051215273 cites W1989230224 @default.
- W2051215273 cites W2018400607 @default.
- W2051215273 cites W2053767245 @default.
- W2051215273 cites W2058135466 @default.
- W2051215273 cites W2061883659 @default.
- W2051215273 cites W2086246426 @default.
- W2051215273 cites W2089894794 @default.
- W2051215273 cites W2091788742 @default.
- W2051215273 cites W2092153331 @default.
- W2051215273 cites W2108693862 @default.
- W2051215273 cites W2111565312 @default.
- W2051215273 cites W2116856707 @default.
- W2051215273 cites W2123952708 @default.
- W2051215273 cites W2127957580 @default.
- W2051215273 cites W2132412147 @default.
- W2051215273 cites W2139295009 @default.
- W2051215273 cites W2140685327 @default.
- W2051215273 cites W2159132836 @default.
- W2051215273 cites W3027137275 @default.
- W2051215273 cites W4238518977 @default.
- W2051215273 cites W4240458335 @default.
- W2051215273 doi "https://doi.org/10.1016/j.ijpara.2012.02.007" @default.
- W2051215273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22619752" @default.
- W2051215273 hasPublicationYear "2012" @default.
- W2051215273 type Work @default.
- W2051215273 sameAs 2051215273 @default.
- W2051215273 citedByCount "6" @default.
- W2051215273 countsByYear W20512152732012 @default.
- W2051215273 countsByYear W20512152732013 @default.
- W2051215273 countsByYear W20512152732014 @default.
- W2051215273 countsByYear W20512152732018 @default.
- W2051215273 countsByYear W20512152732019 @default.
- W2051215273 crossrefType "journal-article" @default.
- W2051215273 hasAuthorship W2051215273A5007413802 @default.
- W2051215273 hasAuthorship W2051215273A5013936064 @default.
- W2051215273 hasAuthorship W2051215273A5014200764 @default.
- W2051215273 hasAuthorship W2051215273A5020308293 @default.
- W2051215273 hasAuthorship W2051215273A5036161938 @default.
- W2051215273 hasAuthorship W2051215273A5049388262 @default.
- W2051215273 hasAuthorship W2051215273A5091678548 @default.
- W2051215273 hasConcept C104317684 @default.
- W2051215273 hasConcept C136764020 @default.
- W2051215273 hasConcept C2776555147 @default.
- W2051215273 hasConcept C2777553398 @default.
- W2051215273 hasConcept C2777923404 @default.
- W2051215273 hasConcept C2777983519 @default.
- W2051215273 hasConcept C2778689377 @default.
- W2051215273 hasConcept C2779761457 @default.
- W2051215273 hasConcept C2781092759 @default.
- W2051215273 hasConcept C2781257258 @default.
- W2051215273 hasConcept C40767141 @default.
- W2051215273 hasConcept C41008148 @default.
- W2051215273 hasConcept C54355233 @default.
- W2051215273 hasConcept C55493867 @default.
- W2051215273 hasConcept C71928629 @default.
- W2051215273 hasConcept C86803240 @default.
- W2051215273 hasConcept C90856448 @default.
- W2051215273 hasConcept C92087593 @default.
- W2051215273 hasConceptScore W2051215273C104317684 @default.
- W2051215273 hasConceptScore W2051215273C136764020 @default.
- W2051215273 hasConceptScore W2051215273C2776555147 @default.
- W2051215273 hasConceptScore W2051215273C2777553398 @default.
- W2051215273 hasConceptScore W2051215273C2777923404 @default.
- W2051215273 hasConceptScore W2051215273C2777983519 @default.
- W2051215273 hasConceptScore W2051215273C2778689377 @default.
- W2051215273 hasConceptScore W2051215273C2779761457 @default.
- W2051215273 hasConceptScore W2051215273C2781092759 @default.
- W2051215273 hasConceptScore W2051215273C2781257258 @default.
- W2051215273 hasConceptScore W2051215273C40767141 @default.
- W2051215273 hasConceptScore W2051215273C41008148 @default.
- W2051215273 hasConceptScore W2051215273C54355233 @default.
- W2051215273 hasConceptScore W2051215273C55493867 @default.
- W2051215273 hasConceptScore W2051215273C71928629 @default.
- W2051215273 hasConceptScore W2051215273C86803240 @default.
- W2051215273 hasConceptScore W2051215273C90856448 @default.
- W2051215273 hasConceptScore W2051215273C92087593 @default.
- W2051215273 hasIssue "4" @default.
- W2051215273 hasLocation W20512152731 @default.
- W2051215273 hasLocation W20512152732 @default.
- W2051215273 hasOpenAccess W2051215273 @default.
- W2051215273 hasPrimaryLocation W20512152731 @default.
- W2051215273 hasRelatedWork W1481029874 @default.
- W2051215273 hasRelatedWork W2002391175 @default.