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• W2051215312 abstract "Annals of the New York Academy of SciencesVolume 398, Issue 1 p. 377-387 ENDORPHIN LEVELS IN OPIOID-DEPENDENT HUMAN SUBJECTS: A LONGITUDINAL STUDY* C. P. O'Brien, C. P. O'Brien Department of Psychiatry, University of Pennsylvania, and Philadelphia Veterans Administration Medical Center, Philadelphia, Pennsylvania 19104Search for more papers by this authorL. Terenius, L. Terenius Department of Pharmacology, University of Uppsala, Uppsala SwedenSearch for more papers by this authorA. Wahlström, A. Wahlström Department of Pharmacology, University of Uppsala, Uppsala SwedenSearch for more papers by this authorA. T. McLellan, A. T. McLellan Department of Psychiatry, University of Pennsylvania, and Philadelphia Veterans Administration Medical Center, Philadelphia, Pennsylvania 19104Search for more papers by this authorW. Krivoy, W. Krivoy National Institute on Drug Abuse, Addiction Research Center, Lexington, Kentucky 40597Search for more papers by this author C. P. O'Brien, C. P. O'Brien Department of Psychiatry, University of Pennsylvania, and Philadelphia Veterans Administration Medical Center, Philadelphia, Pennsylvania 19104Search for more papers by this authorL. Terenius, L. Terenius Department of Pharmacology, University of Uppsala, Uppsala SwedenSearch for more papers by this authorA. Wahlström, A. Wahlström Department of Pharmacology, University of Uppsala, Uppsala SwedenSearch for more papers by this authorA. T. McLellan, A. T. McLellan Department of Psychiatry, University of Pennsylvania, and Philadelphia Veterans Administration Medical Center, Philadelphia, Pennsylvania 19104Search for more papers by this authorW. Krivoy, W. Krivoy National Institute on Drug Abuse, Addiction Research Center, Lexington, Kentucky 40597Search for more papers by this author First published: December 1982 https://doi.org/10.1111/j.1749-6632.1982.tb39509.xCitations: 19 * This work was supported by Grant DA 01505 from the National Institute on Drug Abuse and by the Veterans Administration Medical Research Service. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Pert, C. B. & S. H. Snyder. 1973. Opiate receptor: Demonstration in nervous tissue. Science 179: 1011–1014. 2 Simon, E. I., J. M. Hiller & I. Edelman. 1973. Stereospecific binding of the potent narcotic analgesic 3H-etorphine to rat brain homogenate. Proc. Natl Acad. Sci. USA 70: 1947–1949. 3 Terenius, L. 1973. Characteristics of the “receptor” for narcotic analgesics in synaptic plasma membrane fractions from rat brain. Acta Pharmacol. Toxicol. 33: 377–384. 4 Terenius, L. & A. Wahlström. 1974. Inhibitor(s) of narcotic receptor binding in brain extracts and in cerebrospinal fluid. Acta Pharmacol. (Kbh.) (Suppl. 1) 33: 55. 5 Pasternak, G. W., R. Goodman & S. H. Snyder. 1975. An endogenous morphine-like factor in mammalian brain. Life Sci. 16: 1765–1769. 6 Hughes, J., T. W. Smith, H. W. Kosterlitz, L. Fothergill, B. A. Moyan & H. R. Morris. 1975. Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature 258: 577–579. 7 Fratta, W., H. Y. T. Yany, J. Hong & E. Costa. 1977. Stability of metenkephalin content in brain structures of morphine dependent or foot-shock stressed rats. Nature 268: 452. 8 Childers, S., R. Simintov & S. H. Snyder. 1977. Enkephalin: Radio-immuno-assay and radioreceptor assay in morphine dependent rats. Eur. J. Pharmacol. 46: 289. 9 Wesche, D., V. Hollt & A. Herz. 1977. Radio-immunoassay of enkephalins. Regional distribution in rat brain after morphine treatment and hypophy-sectomy. Naunyn-Schmiedebergs' Arch. Pharmakol. 301: 79. 10 Bergström, L. & L. Terenius. 1979. Enkephalin levels decrease in rat striatum during morphine abstinence. Eur. J. Pharmacol. 60: 349. 11 Przewlocki, R., V. Hollt, T. Duka, G. Lkeber, C. Gramsch, I. Haarmann & A. Herz. 1979. Long term morphine treatment decreases endorphin levels in rat brain and pituitary. Brain Res. 174: 357. 12 Wuster, M., R. Schulz & A. Herz. 1980. Inquiry into endorphinergic feedback mechanisms during the development of opiate tolerance/dependence. Brain Res. 189: 403–411. 13 Malfroy, B., I. P. Swertz, A. Guyon, B. P. Roques & J. C. Swartz. 1978. High affinity enkephalin degrading peptidase in brain is increased after morphine. Nature 276: 523. 14 Clement-Jones, V., L. McLaughlin, P. J. Lowry, G. M. Besser & L. H. Rees. 1979. Acupuncture in heroin addicts: Changes in met-enkephalin and endorphin in blood and cerebrospinal fluid. Lancet ii: 380. 15 Ho, W. K. K., H. L. Wen & N. Ling. 1980. Beta endorphin-like immuno-activity in the plasma of heroin addicts and normal subjects. Neuropharmacology 19: 117. 16 Holmstrand, J., L. M. Gunne, A. Wahlström & L. Terenius. 1981. CSF-endorphins in heroin addicts during methadone maintenance and during withdrawal. Pharmacopsychiatria 14(4): 126–128. 17 Grabowski, J. G., C. P. O'Brien & J. Mintz. 1979. Increasing the likelihood that consent is informed. J. Exp. Anal. Behav. 24: 283–284. 18 McLellan, A. T., L. Luborsky, C. P. O'BRIEN & G. E. Woody. 1980. An improved diagnostic evaluation instrument for substance abuse patients: The Addiction Severity Index. J. Nerv. Ment. Disord. 168: 26–33. 19 Ling, G. F. F., J. G. Umans & C. E. Inturrisi. 1981. Methadone: Radio-immunoassay and pharmacokinetics in the rat. J. Pharmacol. Exp. Ther. 217: 147–151. 20 Lindström, L. H., E. Widerlöv, L. M. Gunne, A. Wahlström & L. Terenius. 1978. Endorphins in human cerebrospinal fluid: Clinical correlations to some psychotic states. Acta Psychiat. Scand. 57: 153–164. 21 Wuster, M., T. Duka & A. Herz. 1980. Diazepam-induced release of opioid activity in the rat brain. Neurosci. Lett. 16: 335–337. 22 Naber, D., D. Pickar, G. C. Davis, R. M. Cohen, D. C. Jimerson, M. A. Elchisak, E. G. Defraites, N. H. Kalin, S. C. Risch & M. S. Buchsbaum. 1981. Naloxone effects on β-endorphin, cortisol, prolactin, growth hormone, HVA and MHPG in plasma of normal volunteers. Psychopharmacologie 74: 125–128. 23 Tang, A. H. & R. J. Collins. 1978. Enhanced analgesic effects of morphine after chronic administration of naloxone in the rat. Eur. J. Pharmacol. 47: 473–476. 24 Schulz, R., M. Wuster & A. Herz. 1979. Supersensitivity to opioids following the chronic blockade of endorphin by naloxone. Arch. Pharmacol. 306: 93–96. 25 Zukin, R. S., E. Gardner & A. R. Gintzler. 1981. Mechanisms of super-sensitivity in the enkephalinergic system. International Narcotics Research Conference, Kyoto, lapan . Abstracts. 8. Citing Literature Volume398, Issue1Opioids in Mental Illness: Theories, Clinical Observations, and Treatment PossibilitiesDecember 1982Pages 377-387 ReferencesRelatedInformation" @default.
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