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- W2051215314 abstract "Quantitative analysis of EEG during wakefulness in AD/MCI patients shows a slowing of EEG rhytms, in terms of increase of delta activity and decrease of alpha activity. Some studies show differences in AD/MCI patients even in EEG sleep: an increase in stage 1, number and length of intra-night awakenings, a decrease of Slow Wave Sleep (SWS) and REM sleep. Given the strong relation (bidirectional) between EEG sleep and wakefullness rhythms, the objective of the study is to assess EEG topography during sleep (REM and NREM) and wakefulness, and to assess relationship between sleep EEG modifications and subsequent variations in wakefulness EEG. 8 patients AD, 13 MCI and 9 elderly healthy people performed one-night sleep PSG recordings (19 cortical electrods, EOG, EMG) and wakefulness EEG recordings (5 min with eyes open and 5 min with eyes closed). Analyses of EEG topography of wakefulness, REM and NREM sleep suggest significant differences between MCI groups vs. controls within the alpha band, in terms of lower EEG activity within this frequency range in patients in occipital and temporal derivations compared to controls. Although preliminary, data of EEG topography seems showing the same functional variations both in sleep and wakefulness. Hence, the observed slowing may be an electrophysiological evidence of neurodegenerative processes at a cortical level." @default.
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- W2051215314 date "2013-11-01" @default.
- W2051215314 modified "2023-09-25" @default.
- W2051215314 title "61. EEG topography of sleep and wakefulness in patients with Mild Cognitive Impairment and Alzheimer Disease: Preliminary data" @default.
- W2051215314 doi "https://doi.org/10.1016/j.clinph.2013.06.088" @default.
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