FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W205121542> ?p ?o ?g. }

• W205121542 endingPage "783" @default.
• W205121542 startingPage "776" @default.
• W205121542 abstract "Abstract The authors have analyzed the involvement of V gamma and J gamma segments in TRG gamma rearrangement from a series of 40 acute lymphoblastic leukemia (ALL), including 25 T- and 15 B-lineage cases, in which TRG gamma are rearranged. Sixty-five rearranged alleles were studied. The authors first describe the cloning and sequencing of two variable segments, V gamma 11 and psi V gamma 12, which rearrange in T- and B-neoplastic cells. To date three subgroups of translatable V gamma segments have been described. The authors show that V gamma 11 is the unique member of a new fourth V gamma subgroup that also rearranges in normal polyclonal T cells and that psi V gamma 12 is located at 5- kilobase (kb) downstream to V gamma 11. As shown by DNA sequence analysis, V gamma 11 shares a 60% homology with V gamma 10 (third subgroup) and a 50% homology with V gamma 9 (second subgroup) but no appreciable homology with the V gamma segments from the first family. In contrast to psi V gamma 12, V gamma 11 is translatable. In this paper the authors have also attempted to determine which V gamma segments were rearranged in the ALL cases by hybridization with a J gamma probe and genomic probes specific of the four subgroups. In the 54 instances in which the rearrangement was consistent with J gamma 1 or J gamma 2 involvement, the authors have identified the corresponding V gamma segments and have not found any other rearrangements suggestive of the existence of further V regions. The V gamma segments, belonging to the first subgroup, were the most frequently used (41 alleles). V gamma 9, V gamma 10, V gamma 11, and psi V gamma 12 were found rearranged in cases 3, 4, 5, and 1, respectively. No cases using the pseudo psi V gamma 1, psi V gamma 5, and psi V gamma 6 segments were found. Pseudo V gamma segments were not found rearranged in T cells, while V gamma 2 and V gamma 4, segments are frequently used. In contrast to the V gamma I gene rearrangement, the involvement of the V gamma II, V gamma III, and V gamma IV subgroups was most frequently observed in T-ALL with stage II differentiation (CD7+, CD4+, and/or CD8+, CD3-), than in those with stage I (CD7+, CD4-, CD8-, CD3-), than in those with stage I (CD7+, CD4-, CD8-, CD3-) and stage III (CD7+, CD4+/-CD8+/-CD3+).(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W205121542 created "2016-06-24" @default.
• W205121542 creator A5002614820 @default.
• W205121542 creator A5007713681 @default.
• W205121542 creator A5028456029 @default.
• W205121542 creator A5074625213 @default.
• W205121542 creator A5075229788 @default.
• W205121542 creator A5082424766 @default.
• W205121542 creator A5090617929 @default.
• W205121542 date "1988-08-01" @default.
• W205121542 modified "2023-09-30" @default.
• W205121542 title "The human T-cell V gamma gene locus: cloning of new segments and study of V gamma rearrangements in neoplastic T and B cells" @default.
• W205121542 cites W1566460254 @default.
• W205121542 cites W1607025084 @default.
• W205121542 cites W1924336654 @default.
• W205121542 cites W1965790014 @default.
• W205121542 cites W1986649211 @default.
• W205121542 cites W1995502028 @default.
• W205121542 cites W2007580564 @default.
• W205121542 cites W2014669590 @default.
• W205121542 cites W2016249716 @default.
• W205121542 cites W2017214831 @default.
• W205121542 cites W2019285553 @default.
• W205121542 cites W2020851010 @default.
• W205121542 cites W2021152296 @default.
• W205121542 cites W2023464965 @default.
• W205121542 cites W2026615255 @default.
• W205121542 cites W2033010633 @default.
• W205121542 cites W2060808906 @default.
• W205121542 cites W2063324561 @default.
• W205121542 cites W2079588771 @default.
• W205121542 cites W2087455989 @default.
• W205121542 cites W2092450783 @default.
• W205121542 cites W2138270253 @default.
• W205121542 cites W30311596 @default.
• W205121542 doi "https://doi.org/10.1182/blood.v72.2.776.776" @default.
• W205121542 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2969758" @default.
• W205121542 hasPublicationYear "1988" @default.
• W205121542 type Work @default.
• W205121542 sameAs 205121542 @default.
• W205121542 citedByCount "65" @default.
• W205121542 countsByYear W2051215422014 @default.
• W205121542 countsByYear W2051215422015 @default.
• W205121542 countsByYear W2051215422016 @default.
• W205121542 crossrefType "journal-article" @default.
• W205121542 hasAuthorship W205121542A5002614820 @default.
• W205121542 hasAuthorship W205121542A5007713681 @default.
• W205121542 hasAuthorship W205121542A5028456029 @default.
• W205121542 hasAuthorship W205121542A5074625213 @default.
• W205121542 hasAuthorship W205121542A5075229788 @default.
• W205121542 hasAuthorship W205121542A5082424766 @default.
• W205121542 hasAuthorship W205121542A5090617929 @default.
• W205121542 hasBestOaLocation W2051215421 @default.
• W205121542 hasConcept C104317684 @default.
• W205121542 hasConcept C121332964 @default.
• W205121542 hasConcept C153911025 @default.
• W205121542 hasConcept C2992511266 @default.
• W205121542 hasConcept C54355233 @default.
• W205121542 hasConcept C86803240 @default.
• W205121542 hasConceptScore W205121542C104317684 @default.
• W205121542 hasConceptScore W205121542C121332964 @default.
• W205121542 hasConceptScore W205121542C153911025 @default.
• W205121542 hasConceptScore W205121542C2992511266 @default.
• W205121542 hasConceptScore W205121542C54355233 @default.
• W205121542 hasConceptScore W205121542C86803240 @default.
• W205121542 hasIssue "2" @default.
• W205121542 hasLocation W2051215421 @default.
• W205121542 hasOpenAccess W205121542 @default.
• W205121542 hasPrimaryLocation W2051215421 @default.
• W205121542 hasRelatedWork W1920751942 @default.
• W205121542 hasRelatedWork W1972383563 @default.
• W205121542 hasRelatedWork W1991523530 @default.
• W205121542 hasRelatedWork W2002128513 @default.
• W205121542 hasRelatedWork W2020824267 @default.
• W205121542 hasRelatedWork W2031436818 @default.
• W205121542 hasRelatedWork W2057739827 @default.
• W205121542 hasRelatedWork W2075354549 @default.
• W205121542 hasRelatedWork W2137690894 @default.
• W205121542 hasRelatedWork W2092874662 @default.
• W205121542 hasVolume "72" @default.
• W205121542 isParatext "false" @default.
• W205121542 isRetracted "false" @default.
• W205121542 magId "205121542" @default.
• W205121542 workType "article" @default.