FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051215626> ?p ?o ?g. }

• W2051215626 endingPage "8804" @default.
• W2051215626 startingPage "8796" @default.
• W2051215626 abstract "Abstract Resistance to chemotherapy remains a major obstacle for the treatment of breast cancer. Understanding the molecular mechanism(s) of resistance is crucial for the development of new effective therapies to treat this disease. This study examines the putative role of p130Cas (Cas) in resistance to the cytotoxic agent Adriamycin. High expression of Cas in primary breast tumors is associated with the failure to respond to the antiestrogen tamoxifen and poor prognosis, highlighting the potential clinical importance of this molecule. Here, we show a novel association between Cas and resistance to Adriamycin. We show that Cas overexpression renders MCF-7 breast cancer cells less sensitive to the growth inhibitory and proapoptotic effects of Adriamycin. The catalytic activity of the nonreceptor tyrosine kinase c-Src, but not the epidermal growth factor receptor, is critical for Cas-mediated protection from Adriamycin-induced death. The phosphorylation of Akt and extracellular signal-regulated kinase 1/2 (ERK1/2) is elevated in Cas-overexpressing cells treated with Adriamycin, whereas expression of the proapoptotic protein Bak is decreased. Conversely, Cas depletion in the more resistant T47D and MDA-MB-231 cell lines increases sensitivity to Adriamycin. Based on these data, we propose that Cas activates growth and survival pathways regulated by c-Src, Akt, and ERK1/2 that lead to the inhibition of mitochondrial-mediated apoptosis in the presence of Adriamycin. Because Cas is frequently expressed at high levels in breast cancers, these findings raise the possibility of resensitizing Cas-overexpressing tumors to chemotherapy through perturbation of Cas signaling pathways. [Cancer Res 2008;68(21):8796–804]" @default.
• W2051215626 created "2016-06-24" @default.
• W2051215626 creator A5030878951 @default.
• W2051215626 creator A5042682650 @default.
• W2051215626 creator A5052385827 @default.
• W2051215626 creator A5074287120 @default.
• W2051215626 date "2008-10-30" @default.
• W2051215626 modified "2023-09-27" @default.
• W2051215626 title "A Novel Association between p130Cas and Resistance to the Chemotherapeutic Drug Adriamycin in Human Breast Cancer Cells" @default.
• W2051215626 cites W1849793110 @default.
• W2051215626 cites W1900495018 @default.
• W2051215626 cites W1933433305 @default.
• W2051215626 cites W1967331103 @default.
• W2051215626 cites W1968973290 @default.
• W2051215626 cites W1969405269 @default.
• W2051215626 cites W1974302097 @default.
• W2051215626 cites W1984789674 @default.
• W2051215626 cites W2004992894 @default.
• W2051215626 cites W2025491667 @default.
• W2051215626 cites W2034716886 @default.
• W2051215626 cites W2042834671 @default.
• W2051215626 cites W2045563337 @default.
• W2051215626 cites W2050675499 @default.
• W2051215626 cites W2060811507 @default.
• W2051215626 cites W2068722668 @default.
• W2051215626 cites W2069295237 @default.
• W2051215626 cites W2078818685 @default.
• W2051215626 cites W2088714384 @default.
• W2051215626 cites W2094366341 @default.
• W2051215626 cites W2096772718 @default.
• W2051215626 cites W2097538017 @default.
• W2051215626 cites W2098837223 @default.
• W2051215626 cites W2103156288 @default.
• W2051215626 cites W2110578000 @default.
• W2051215626 cites W2120212941 @default.
• W2051215626 cites W2128920100 @default.
• W2051215626 cites W2134632109 @default.
• W2051215626 cites W2135619115 @default.
• W2051215626 cites W2138679062 @default.
• W2051215626 cites W2138782161 @default.
• W2051215626 cites W2140427830 @default.
• W2051215626 cites W2142538732 @default.
• W2051215626 cites W2144829593 @default.
• W2051215626 cites W2145012366 @default.
• W2051215626 cites W2146973482 @default.
• W2051215626 cites W2151791302 @default.
• W2051215626 cites W2153122962 @default.
• W2051215626 cites W2170278621 @default.
• W2051215626 cites W2314543545 @default.
• W2051215626 doi "https://doi.org/10.1158/0008-5472.can-08-2426" @default.
• W2051215626 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2597570" @default.
• W2051215626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18974122" @default.
• W2051215626 hasPublicationYear "2008" @default.
• W2051215626 type Work @default.
• W2051215626 sameAs 2051215626 @default.
• W2051215626 citedByCount "50" @default.
• W2051215626 countsByYear W20512156262012 @default.
• W2051215626 countsByYear W20512156262013 @default.
• W2051215626 countsByYear W20512156262014 @default.
• W2051215626 countsByYear W20512156262015 @default.
• W2051215626 countsByYear W20512156262016 @default.
• W2051215626 countsByYear W20512156262017 @default.
• W2051215626 countsByYear W20512156262018 @default.
• W2051215626 countsByYear W20512156262019 @default.
• W2051215626 countsByYear W20512156262020 @default.
• W2051215626 countsByYear W20512156262021 @default.
• W2051215626 countsByYear W20512156262022 @default.
• W2051215626 countsByYear W20512156262023 @default.
• W2051215626 crossrefType "journal-article" @default.
• W2051215626 hasAuthorship W2051215626A5030878951 @default.
• W2051215626 hasAuthorship W2051215626A5042682650 @default.
• W2051215626 hasAuthorship W2051215626A5052385827 @default.
• W2051215626 hasAuthorship W2051215626A5074287120 @default.
• W2051215626 hasBestOaLocation W20512156261 @default.
• W2051215626 hasConcept C108636557 @default.
• W2051215626 hasConcept C121608353 @default.
• W2051215626 hasConcept C126322002 @default.
• W2051215626 hasConcept C184235292 @default.
• W2051215626 hasConcept C190283241 @default.
• W2051215626 hasConcept C2776067312 @default.
• W2051215626 hasConcept C2776694085 @default.
• W2051215626 hasConcept C2777176818 @default.
• W2051215626 hasConcept C2781303535 @default.
• W2051215626 hasConcept C42362537 @default.
• W2051215626 hasConcept C502942594 @default.
• W2051215626 hasConcept C530470458 @default.
• W2051215626 hasConcept C55493867 @default.
• W2051215626 hasConcept C62478195 @default.
• W2051215626 hasConcept C71924100 @default.
• W2051215626 hasConcept C75217442 @default.
• W2051215626 hasConcept C86803240 @default.
• W2051215626 hasConcept C95444343 @default.
• W2051215626 hasConceptScore W2051215626C108636557 @default.
• W2051215626 hasConceptScore W2051215626C121608353 @default.
• W2051215626 hasConceptScore W2051215626C126322002 @default.
• W2051215626 hasConceptScore W2051215626C184235292 @default.
• W2051215626 hasConceptScore W2051215626C190283241 @default.
• W2051215626 hasConceptScore W2051215626C2776067312 @default.

• next