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- W2051215698 abstract "Lasp-1 and lasp-2 are actin-binding proteins that contain a LIM domain, two nebulin repeats and an SH3 domain with significant identity. We determined the chromosomal locations of the <i>LASP1</i> and <i>LASP2</i> genes in chicken by fluorescence in situ hybridization. The <i>LASP1 </i>gene was localized to a pair of microchromosomes and the <i>LASP2</i> gene was localized to chromosome 2p3.1, indicating that the chromosomal locations of the <i>LASP1</i> and <i>LASP2</i> genes are highly conserved between chicken and human. The comparison of genomic and cDNA sequences of chicken lasp-2 and nebulette, a nebulin-related protein in muscle, suggested that both the corresponding mRNAs shared exons in the same manner as their human homologues. When compared with the domain structure of nebulette, another nebulin repeat was predicted for lasp-2, and all the nebulin repeats of lasp-2 were better conserved than those in nebulette. We also found the exon boundaries in nebulin repeats of lasp-2 were similar to those of other nebulin-related proteins." @default.
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- W2051215698 date "2005-11-03" @default.
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- W2051215698 title "Chromosomal assignment of <i>LASP1</i> and <i>LASP2</i> genes and organization of the <i>LASP2</i> gene in chicken" @default.
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- W2051215698 doi "https://doi.org/10.1159/000087526" @default.
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