FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051215700> ?p ?o ?g. }

• W2051215700 endingPage "5320" @default.
• W2051215700 startingPage "5317" @default.
• W2051215700 abstract "Knowledge of the role of individual side chains in forming different secondary structures such as the alpha-helix would be useful for prediction of protein structure from sequence or de novo protein design. Experimental and theoretical studies on natural and synthetic peptides and proteins indicate that individual side chains differ in their helix-forming potential. Four aliphatic side chains occur in the standard complement of amino acids: alanine and leucine are helix stabilizing, whereas isoleucine and valine are weakly destabilizing. We have synthesized a series of helical peptides containing unnatural aliphatic side chains having two to four carbons to explore some of the factors involved in alpha-helix stabilization and the basis for selection of the natural set. We find that linear side chains with two, three, or four carbons are as strongly helix stabilizing as the single methyl in alanine and that all linear side chains are stronger helix promoters than leucine. In addition, a t-butyl side chain is significantly more helix destabilizing than the sec-butyl side chain of isoleucine, the isopropyl side chain of valine, or even the unrestricted side chain of glycine. These results provide experimental evidence that restriction in conformational freedom of a side chain imposed by alpha-helix formation is a major component of the role of a side chain in stabilizing helical structure." @default.
• W2051215700 created "2016-06-24" @default.
• W2051215700 creator A5000341676 @default.
• W2051215700 creator A5028741023 @default.
• W2051215700 creator A5039915636 @default.
• W2051215700 creator A5081454326 @default.
• W2051215700 date "1991-06-15" @default.
• W2051215700 modified "2023-10-16" @default.
• W2051215700 title "Alpha-helix stabilization by natural and unnatural amino acids with alkyl side chains." @default.
• W2051215700 cites W1574312817 @default.
• W2051215700 cites W1968673134 @default.
• W2051215700 cites W1975760681 @default.
• W2051215700 cites W1980022131 @default.
• W2051215700 cites W1995809651 @default.
• W2051215700 cites W1995938191 @default.
• W2051215700 cites W1999306340 @default.
• W2051215700 cites W2001350069 @default.
• W2051215700 cites W2003697928 @default.
• W2051215700 cites W2019419950 @default.
• W2051215700 cites W2037631365 @default.
• W2051215700 cites W2039388179 @default.
• W2051215700 cites W2053955426 @default.
• W2051215700 cites W2056770911 @default.
• W2051215700 cites W2057553906 @default.
• W2051215700 cites W2081359387 @default.
• W2051215700 cites W2087082736 @default.
• W2051215700 cites W2087752405 @default.
• W2051215700 cites W2088857516 @default.
• W2051215700 cites W2094294218 @default.
• W2051215700 cites W2125793518 @default.
• W2051215700 cites W2162033620 @default.
• W2051215700 cites W2167839173 @default.
• W2051215700 cites W2173534031 @default.
• W2051215700 doi "https://doi.org/10.1073/pnas.88.12.5317" @default.
• W2051215700 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/51863" @default.
• W2051215700 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2052608" @default.
• W2051215700 hasPublicationYear "1991" @default.
• W2051215700 type Work @default.
• W2051215700 sameAs 2051215700 @default.
• W2051215700 citedByCount "167" @default.
• W2051215700 countsByYear W20512157002012 @default.
• W2051215700 countsByYear W20512157002013 @default.
• W2051215700 countsByYear W20512157002014 @default.
• W2051215700 countsByYear W20512157002015 @default.
• W2051215700 countsByYear W20512157002016 @default.
• W2051215700 countsByYear W20512157002017 @default.
• W2051215700 countsByYear W20512157002018 @default.
• W2051215700 countsByYear W20512157002019 @default.
• W2051215700 countsByYear W20512157002020 @default.
• W2051215700 countsByYear W20512157002021 @default.
• W2051215700 countsByYear W20512157002022 @default.
• W2051215700 countsByYear W20512157002023 @default.
• W2051215700 crossrefType "journal-article" @default.
• W2051215700 hasAuthorship W2051215700A5000341676 @default.
• W2051215700 hasAuthorship W2051215700A5028741023 @default.
• W2051215700 hasAuthorship W2051215700A5039915636 @default.
• W2051215700 hasAuthorship W2051215700A5081454326 @default.
• W2051215700 hasBestOaLocation W20512157002 @default.
• W2051215700 hasConcept C133571119 @default.
• W2051215700 hasConcept C178790620 @default.
• W2051215700 hasConcept C184538305 @default.
• W2051215700 hasConcept C185592680 @default.
• W2051215700 hasConcept C18903297 @default.
• W2051215700 hasConcept C204921945 @default.
• W2051215700 hasConcept C2776580952 @default.
• W2051215700 hasConcept C2777305461 @default.
• W2051215700 hasConcept C2777573094 @default.
• W2051215700 hasConcept C2778530040 @default.
• W2051215700 hasConcept C2779856020 @default.
• W2051215700 hasConcept C2779965526 @default.
• W2051215700 hasConcept C47701112 @default.
• W2051215700 hasConcept C515207424 @default.
• W2051215700 hasConcept C521977710 @default.
• W2051215700 hasConcept C55493867 @default.
• W2051215700 hasConcept C71240020 @default.
• W2051215700 hasConcept C86803240 @default.
• W2051215700 hasConceptScore W2051215700C133571119 @default.
• W2051215700 hasConceptScore W2051215700C178790620 @default.
• W2051215700 hasConceptScore W2051215700C184538305 @default.
• W2051215700 hasConceptScore W2051215700C185592680 @default.
• W2051215700 hasConceptScore W2051215700C18903297 @default.
• W2051215700 hasConceptScore W2051215700C204921945 @default.
• W2051215700 hasConceptScore W2051215700C2776580952 @default.
• W2051215700 hasConceptScore W2051215700C2777305461 @default.
• W2051215700 hasConceptScore W2051215700C2777573094 @default.
• W2051215700 hasConceptScore W2051215700C2778530040 @default.
• W2051215700 hasConceptScore W2051215700C2779856020 @default.
• W2051215700 hasConceptScore W2051215700C2779965526 @default.
• W2051215700 hasConceptScore W2051215700C47701112 @default.
• W2051215700 hasConceptScore W2051215700C515207424 @default.
• W2051215700 hasConceptScore W2051215700C521977710 @default.
• W2051215700 hasConceptScore W2051215700C55493867 @default.
• W2051215700 hasConceptScore W2051215700C71240020 @default.
• W2051215700 hasConceptScore W2051215700C86803240 @default.
• W2051215700 hasIssue "12" @default.
• W2051215700 hasLocation W20512157001 @default.
• W2051215700 hasLocation W20512157002 @default.
• W2051215700 hasLocation W20512157003 @default.

• next