FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051216049> ?p ?o ?g. }

• W2051216049 endingPage "35835" @default.
• W2051216049 startingPage "35825" @default.
• W2051216049 abstract "The deletion of phenylalanine 508 in the first nucleotide binding domain of the cystic fibrosis transmembrane conductance regulator is directly associated with >90% of cystic fibrosis cases. This mutant protein fails to traffic out of the endoplasmic reticulum and is subsequently degraded by the proteasome. The effects of this mutation may be partially reversed by the application of exogenous osmolytes, expression at low temperature, and the introduction of second site suppressor mutations. However, the specific steps of folding and assembly of full-length cystic fibrosis transmembrane conductance regulator (CFTR) directly altered by the disease-causing mutation are unclear. To elucidate the effects of the ΔF508 mutation, on various steps in CFTR folding, a series of misfolding and suppressor mutations in the nucleotide binding and transmembrane domains were evaluated for effects on the folding and maturation of the protein. The results indicate that the isolated NBD1 responds to both the ΔF508 mutation and intradomain suppressors of this mutation. In addition, identification of a novel second site suppressor of the defect within the second transmembrane domain suggests that ΔF508 also effects interdomain interactions critical for later steps in the biosynthesis of CFTR." @default.
• W2051216049 created "2016-06-24" @default.
• W2051216049 creator A5010899423 @default.
• W2051216049 creator A5014029646 @default.
• W2051216049 creator A5021537483 @default.
• W2051216049 creator A5025268008 @default.
• W2051216049 creator A5031703694 @default.
• W2051216049 creator A5042047114 @default.
• W2051216049 creator A5046597133 @default.
• W2051216049 creator A5049576480 @default.
• W2051216049 creator A5052136826 @default.
• W2051216049 creator A5054545059 @default.
• W2051216049 creator A5063122772 @default.
• W2051216049 creator A5066672773 @default.
• W2051216049 date "2010-11-01" @default.
• W2051216049 modified "2023-10-12" @default.
• W2051216049 title "The Cystic Fibrosis-causing Mutation ΔF508 Affects Multiple Steps in Cystic Fibrosis Transmembrane Conductance Regulator Biogenesis" @default.
• W2051216049 cites W120703973 @default.
• W2051216049 cites W1557039381 @default.
• W2051216049 cites W1583685756 @default.
• W2051216049 cites W1602887917 @default.
• W2051216049 cites W1977353319 @default.
• W2051216049 cites W1978905291 @default.
• W2051216049 cites W1981893537 @default.
• W2051216049 cites W1983544779 @default.
• W2051216049 cites W1993655108 @default.
• W2051216049 cites W1996779865 @default.
• W2051216049 cites W2000151968 @default.
• W2051216049 cites W2002858846 @default.
• W2051216049 cites W2004844038 @default.
• W2051216049 cites W2006439869 @default.
• W2051216049 cites W2016265972 @default.
• W2051216049 cites W2018414056 @default.
• W2051216049 cites W2021904069 @default.
• W2051216049 cites W2023369702 @default.
• W2051216049 cites W2032258216 @default.
• W2051216049 cites W2039599894 @default.
• W2051216049 cites W2040690917 @default.
• W2051216049 cites W2049696186 @default.
• W2051216049 cites W2050662826 @default.
• W2051216049 cites W2053317847 @default.
• W2051216049 cites W2061543226 @default.
• W2051216049 cites W2063623087 @default.
• W2051216049 cites W2066529924 @default.
• W2051216049 cites W2067308664 @default.
• W2051216049 cites W2070043042 @default.
• W2051216049 cites W2079234445 @default.
• W2051216049 cites W2079521511 @default.
• W2051216049 cites W2088118742 @default.
• W2051216049 cites W2088337203 @default.
• W2051216049 cites W2099245798 @default.
• W2051216049 cites W2137704498 @default.
• W2051216049 cites W2139398847 @default.
• W2051216049 cites W2146335990 @default.
• W2051216049 cites W2150675272 @default.
• W2051216049 cites W2161849629 @default.
• W2051216049 cites W2161983628 @default.
• W2051216049 cites W2171278423 @default.
• W2051216049 doi "https://doi.org/10.1074/jbc.m110.131623" @default.
• W2051216049 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2975206" @default.
• W2051216049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20667826" @default.
• W2051216049 hasPublicationYear "2010" @default.
• W2051216049 type Work @default.
• W2051216049 sameAs 2051216049 @default.
• W2051216049 citedByCount "161" @default.
• W2051216049 countsByYear W20512160492012 @default.
• W2051216049 countsByYear W20512160492013 @default.
• W2051216049 countsByYear W20512160492014 @default.
• W2051216049 countsByYear W20512160492015 @default.
• W2051216049 countsByYear W20512160492016 @default.
• W2051216049 countsByYear W20512160492017 @default.
• W2051216049 countsByYear W20512160492018 @default.
• W2051216049 countsByYear W20512160492019 @default.
• W2051216049 countsByYear W20512160492020 @default.
• W2051216049 countsByYear W20512160492021 @default.
• W2051216049 countsByYear W20512160492022 @default.
• W2051216049 countsByYear W20512160492023 @default.
• W2051216049 crossrefType "journal-article" @default.
• W2051216049 hasAuthorship W2051216049A5010899423 @default.
• W2051216049 hasAuthorship W2051216049A5014029646 @default.
• W2051216049 hasAuthorship W2051216049A5021537483 @default.
• W2051216049 hasAuthorship W2051216049A5025268008 @default.
• W2051216049 hasAuthorship W2051216049A5031703694 @default.
• W2051216049 hasAuthorship W2051216049A5042047114 @default.
• W2051216049 hasAuthorship W2051216049A5046597133 @default.
• W2051216049 hasAuthorship W2051216049A5049576480 @default.
• W2051216049 hasAuthorship W2051216049A5052136826 @default.
• W2051216049 hasAuthorship W2051216049A5054545059 @default.
• W2051216049 hasAuthorship W2051216049A5063122772 @default.
• W2051216049 hasAuthorship W2051216049A5066672773 @default.
• W2051216049 hasBestOaLocation W20512160491 @default.
• W2051216049 hasConcept C104317684 @default.
• W2051216049 hasConcept C113027372 @default.
• W2051216049 hasConcept C118892022 @default.
• W2051216049 hasConcept C131934819 @default.
• W2051216049 hasConcept C143065580 @default.
• W2051216049 hasConcept C158617107 @default.
• W2051216049 hasConcept C170493617 @default.

• next