FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051216950> ?p ?o ?g. }

• W2051216950 endingPage "201" @default.
• W2051216950 startingPage "193" @default.
• W2051216950 abstract "The severity of ethanol-induced liver injury is associated with oxidative stress and lipid accumulation in the liver. Core circadian clock is known to mediate antioxidative enzyme activity and lipid metabolism. However, the link between circadian clock and ethanol-induced hepatotoxicity remains unclear. Here we showed that extents of acute ethanol-induced liver injury and steatosis in mice exhibit circadian variations consistent with hepatic expression of Period (Per) genes. Mice lacking clock gene Per1 displayed less susceptible to ethanol-induced liver injury, as evidenced by lower serum transaminase activity and less severe histopathological changes. Ethanol-induced lipid peroxidation was alleviated in Per1-/- mice. However, Per1 deletion had no effect on antioxidants depletion caused by ethanol administration. Ethanol-induced triglycerides (TG) accumulation in the serum and liver was significantly decreased in Per1-/- mice compared with that in wild-type (WT) mice. Analysis of gene expression in the liver revealed peroxisome proliferators activated receptor-gamma (PPARγ) and its target genes related to TG synthesis are remarkably down-regulated in Per1-/- mice. HepG2 cells were treated with ethanol at 150 mM for 3 days. Per1 overexpression augmented lipid accumulation after treatment with ethanol in HepG2 cells, but had no effect on ethanol-induced oxidative stress. Expression of genes related to lipogenesis, including PPARγ and its target genes, was up-regulated in cells overexpressing Per1. In conclusion, these results indicated that circadian rhythms of ethanol-induced hepatotoxicity are controlled by clock gene Per1, and deletion of Per1 protected mice from ethanol-induced liver injury by decreasing hepatic lipid accumulation." @default.
• W2051216950 created "2016-06-24" @default.
• W2051216950 creator A5012201858 @default.
• W2051216950 creator A5024481672 @default.
• W2051216950 creator A5030869525 @default.
• W2051216950 creator A5034665747 @default.
• W2051216950 creator A5039358700 @default.
• W2051216950 creator A5085142676 @default.
• W2051216950 date "2013-12-01" @default.
• W2051216950 modified "2023-10-02" @default.
• W2051216950 title "Deletion of circadian gene Per1 alleviates acute ethanol-induced hepatotoxicity in mice" @default.
• W2051216950 cites W1535922733 @default.
• W2051216950 cites W1654008137 @default.
• W2051216950 cites W1894018731 @default.
• W2051216950 cites W1974796362 @default.
• W2051216950 cites W1982920286 @default.
• W2051216950 cites W1983003002 @default.
• W2051216950 cites W1985233700 @default.
• W2051216950 cites W2003302378 @default.
• W2051216950 cites W2003512204 @default.
• W2051216950 cites W2005141055 @default.
• W2051216950 cites W2014631569 @default.
• W2051216950 cites W2015248730 @default.
• W2051216950 cites W2017721030 @default.
• W2051216950 cites W2018255482 @default.
• W2051216950 cites W2021229976 @default.
• W2051216950 cites W2026201390 @default.
• W2051216950 cites W2033522281 @default.
• W2051216950 cites W2038579078 @default.
• W2051216950 cites W2042083001 @default.
• W2051216950 cites W2043535635 @default.
• W2051216950 cites W2045697780 @default.
• W2051216950 cites W2058843590 @default.
• W2051216950 cites W2070647828 @default.
• W2051216950 cites W2075091287 @default.
• W2051216950 cites W2077390673 @default.
• W2051216950 cites W2089749987 @default.
• W2051216950 cites W2090668537 @default.
• W2051216950 cites W2094002997 @default.
• W2051216950 cites W2095436953 @default.
• W2051216950 cites W2128073839 @default.
• W2051216950 cites W2130618859 @default.
• W2051216950 cites W2136163260 @default.
• W2051216950 cites W2152201022 @default.
• W2051216950 cites W2152862264 @default.
• W2051216950 cites W2330531668 @default.
• W2051216950 cites W36612387 @default.
• W2051216950 doi "https://doi.org/10.1016/j.tox.2013.09.009" @default.
• W2051216950 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24144995" @default.
• W2051216950 hasPublicationYear "2013" @default.
• W2051216950 type Work @default.
• W2051216950 sameAs 2051216950 @default.
• W2051216950 citedByCount "32" @default.
• W2051216950 countsByYear W20512169502014 @default.
• W2051216950 countsByYear W20512169502015 @default.
• W2051216950 countsByYear W20512169502016 @default.
• W2051216950 countsByYear W20512169502017 @default.
• W2051216950 countsByYear W20512169502018 @default.
• W2051216950 countsByYear W20512169502019 @default.
• W2051216950 countsByYear W20512169502021 @default.
• W2051216950 countsByYear W20512169502022 @default.
• W2051216950 countsByYear W20512169502023 @default.
• W2051216950 crossrefType "journal-article" @default.
• W2051216950 hasAuthorship W2051216950A5012201858 @default.
• W2051216950 hasAuthorship W2051216950A5024481672 @default.
• W2051216950 hasAuthorship W2051216950A5030869525 @default.
• W2051216950 hasAuthorship W2051216950A5034665747 @default.
• W2051216950 hasAuthorship W2051216950A5039358700 @default.
• W2051216950 hasAuthorship W2051216950A5085142676 @default.
• W2051216950 hasConcept C121446783 @default.
• W2051216950 hasConcept C126322002 @default.
• W2051216950 hasConcept C134018914 @default.
• W2051216950 hasConcept C141359234 @default.
• W2051216950 hasConcept C184738001 @default.
• W2051216950 hasConcept C185592680 @default.
• W2051216950 hasConcept C2776151105 @default.
• W2051216950 hasConcept C2776175330 @default.
• W2051216950 hasConcept C2776637226 @default.
• W2051216950 hasConcept C2780360009 @default.
• W2051216950 hasConcept C2780829032 @default.
• W2051216950 hasConcept C38606739 @default.
• W2051216950 hasConcept C4733338 @default.
• W2051216950 hasConcept C71924100 @default.
• W2051216950 hasConcept C86803240 @default.
• W2051216950 hasConceptScore W2051216950C121446783 @default.
• W2051216950 hasConceptScore W2051216950C126322002 @default.
• W2051216950 hasConceptScore W2051216950C134018914 @default.
• W2051216950 hasConceptScore W2051216950C141359234 @default.
• W2051216950 hasConceptScore W2051216950C184738001 @default.
• W2051216950 hasConceptScore W2051216950C185592680 @default.
• W2051216950 hasConceptScore W2051216950C2776151105 @default.
• W2051216950 hasConceptScore W2051216950C2776175330 @default.
• W2051216950 hasConceptScore W2051216950C2776637226 @default.
• W2051216950 hasConceptScore W2051216950C2780360009 @default.
• W2051216950 hasConceptScore W2051216950C2780829032 @default.
• W2051216950 hasConceptScore W2051216950C38606739 @default.
• W2051216950 hasConceptScore W2051216950C4733338 @default.
• W2051216950 hasConceptScore W2051216950C71924100 @default.

• next