Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051217533> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2051217533 endingPage "tw54" @default.
- W2051217533 startingPage "tw54" @default.
- W2051217533 abstract "The striatum controls motor activity through the balance of the activity of a direct and indirect pathway. Kreitzer and Malenka used mice engineered to express green fluorescent protein in neurons of the direct pathway or indirect pathway to show that the cells of the indirect pathway exhibited (i) higher probability of neurotransmitter release, (ii) increased ratios of NMDA- to AMPA-type glutamate receptors, and (iii) increased rate of synaptic activity compared with cells of the direct pathway. High-frequency afferent stimulation only triggered long-term depression (LTD) in the indirect pathway, and application of an antagonist of the endocannabinoid receptor CB1 or the D2 dopamine receptor blocked this response. However, this difference was not caused by a lack of CB1 receptors in the direct pathway, because application of CB1 agonist increased both direct and indirect pathway excitatory postsynaptic potentials. Instead, endocannabinoid release or synthesis in response to synaptic activity appeared to be limited to the indirect pathway. Mouse models of Parkinson's disease showed a lack of an indirect pathway LTD response that was restored if the slices were exposed to a D2 agonist or an inhibitor of endocannabinoid degradation. In the Parkinson's model mice, treatment with both a D2 agonist and the endocannabinoid degradation inhibitor reduced catalepsy and improved motor activity compared to treatment with the D2 agonist alone." @default.
- W2051217533 created "2016-06-24" @default.
- W2051217533 creator A5056409786 @default.
- W2051217533 date "2007-02-06" @default.
- W2051217533 modified "2023-09-24" @default.
- W2051217533 title "Shifting the Balance" @default.
- W2051217533 doi "https://doi.org/10.1126/stke.3732007tw54" @default.
- W2051217533 hasPublicationYear "2007" @default.
- W2051217533 type Work @default.
- W2051217533 sameAs 2051217533 @default.
- W2051217533 citedByCount "0" @default.
- W2051217533 crossrefType "journal-article" @default.
- W2051217533 hasAuthorship W2051217533A5056409786 @default.
- W2051217533 hasConcept C126322002 @default.
- W2051217533 hasConcept C134018914 @default.
- W2051217533 hasConcept C148001335 @default.
- W2051217533 hasConcept C148132819 @default.
- W2051217533 hasConcept C160268369 @default.
- W2051217533 hasConcept C162536842 @default.
- W2051217533 hasConcept C170493617 @default.
- W2051217533 hasConcept C185592680 @default.
- W2051217533 hasConcept C2778938600 @default.
- W2051217533 hasConcept C2780062018 @default.
- W2051217533 hasConcept C44208683 @default.
- W2051217533 hasConcept C46721173 @default.
- W2051217533 hasConcept C513476851 @default.
- W2051217533 hasConcept C55493867 @default.
- W2051217533 hasConcept C61174792 @default.
- W2051217533 hasConcept C71924100 @default.
- W2051217533 hasConcept C73009533 @default.
- W2051217533 hasConcept C86803240 @default.
- W2051217533 hasConcept C98274493 @default.
- W2051217533 hasConceptScore W2051217533C126322002 @default.
- W2051217533 hasConceptScore W2051217533C134018914 @default.
- W2051217533 hasConceptScore W2051217533C148001335 @default.
- W2051217533 hasConceptScore W2051217533C148132819 @default.
- W2051217533 hasConceptScore W2051217533C160268369 @default.
- W2051217533 hasConceptScore W2051217533C162536842 @default.
- W2051217533 hasConceptScore W2051217533C170493617 @default.
- W2051217533 hasConceptScore W2051217533C185592680 @default.
- W2051217533 hasConceptScore W2051217533C2778938600 @default.
- W2051217533 hasConceptScore W2051217533C2780062018 @default.
- W2051217533 hasConceptScore W2051217533C44208683 @default.
- W2051217533 hasConceptScore W2051217533C46721173 @default.
- W2051217533 hasConceptScore W2051217533C513476851 @default.
- W2051217533 hasConceptScore W2051217533C55493867 @default.
- W2051217533 hasConceptScore W2051217533C61174792 @default.
- W2051217533 hasConceptScore W2051217533C71924100 @default.
- W2051217533 hasConceptScore W2051217533C73009533 @default.
- W2051217533 hasConceptScore W2051217533C86803240 @default.
- W2051217533 hasConceptScore W2051217533C98274493 @default.
- W2051217533 hasIssue "373" @default.
- W2051217533 hasLocation W20512175331 @default.
- W2051217533 hasOpenAccess W2051217533 @default.
- W2051217533 hasPrimaryLocation W20512175331 @default.
- W2051217533 hasRelatedWork W1988622381 @default.
- W2051217533 hasRelatedWork W1989056233 @default.
- W2051217533 hasRelatedWork W2016871471 @default.
- W2051217533 hasRelatedWork W2025676835 @default.
- W2051217533 hasRelatedWork W2051217533 @default.
- W2051217533 hasRelatedWork W2077065536 @default.
- W2051217533 hasRelatedWork W2184087358 @default.
- W2051217533 hasRelatedWork W2802075251 @default.
- W2051217533 hasRelatedWork W2883561796 @default.
- W2051217533 hasRelatedWork W3105506234 @default.
- W2051217533 hasVolume "2007" @default.
- W2051217533 isParatext "false" @default.
- W2051217533 isRetracted "false" @default.
- W2051217533 magId "2051217533" @default.
- W2051217533 workType "article" @default.