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• W2051217727 startingPage "256" @default.
• W2051217727 abstract "Chromatin remodeling plays a key role in the transcriptional activation of regulatory factors in the liver in response to a variety of stress signals. The effects of burn injury on histone expression and its modification were investigated in this study. Liver tissues collected after a flame burn injury were subjected to RT-PCR and Western blot analyses of histone regulation. There was a marked induction of histone H3-D variant mRNA at 3 and 6 h. In contrast, histone H2A.2 variant mRNA had a downregulation at 3 days. No apparent changes were noted in other histone variants examined. Western blot analysis revealed a downregulation of all 5 histone subtypes (H1, H2A, H2B, H3, and H4) at 1 day and there was a subsequent induction of H1 and H2A subtypes at 3 days after injury. There was an induction of modified forms (phospho-, acetyl-, and dimethyl-) of histone H3 subtype at day 3. Furthermore, a transient elevation in PCNA (proliferating cell nuclear antigen) levels was apparent in the liver at day 3, which parallels the induction of phospho-histone H3, which is a mitosis marker. These findings suggest that histones participate in a cascade of events associated with phenotypic alterations in the liver after injury." @default.
• W2051217727 created "2016-06-24" @default.
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• W2051217727 date "2003-12-01" @default.
• W2051217727 modified "2023-09-27" @default.
• W2051217727 title "Alterations in the expression and modification of histonesin the liver after injury" @default.
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• W2051217727 doi "https://doi.org/10.1016/s0014-4800(03)00095-9" @default.
• W2051217727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14611817" @default.
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