FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051217866> ?p ?o ?g. }

• W2051217866 endingPage "259" @default.
• W2051217866 startingPage "251" @default.
• W2051217866 abstract "Hemokinin-1 (HK-1) is a novel member of the tachykinin family that is encoded by preprotachykinin 4 (TAC4) and shares the neurokinin-1 receptor (NK1-R) with substance P (SP). Although HK-1 is thought to be an endogenous peripheral SP-like endocrine or paracrine molecule in locations where SP is not expressed, neither the distribution of HK-1 in the maxillofacial area nor the role HK-1 in bone tissue have been examined. In this study, we investigated the distribution of HK-1 in trigeminal ganglion (TG) and maxillary bone, and assessed the expression of HK-1 during osteoclast differentiation. In vivo, rat molars were loaded for 5 days using the Waldo method. In vitro, rat osteoclast-like cells were induced from bone marrow cells. HK-1 distribution and expression were examined by immunofluorescence staining and reverse transcription polymerase chain reaction (RT-PCR). In vivo, HK-1 was localized in rat TG neurons; however, the number of HK-1-positive neurons was less than that of SP-positive neurons. In the maxillary bone, nerve fibers, blood vessels, and osteocytes were immunopositive for HK-1. Furthermore, HK-1-positive immunoreactivity was found in osteoclasts on the pressure side. In vitro, PCR showed that TAC4 and NK1-R mRNA was expressed in osteoclasts as well as in bone marrow cells. Although SP (10⁻⁷ M) treatment led to an increased number of osteoclasts, HK-1 (10⁻⁷ M) treatment did not. The numbers of biotin-labeled HK-1 peptides bound osteoclasts significantly decreased upon incubation with unlabeled SP and biotin-labeled HK-1 compared with biotin-labeled HK-1 alone. These results suggest that HK-1 may not stimulate the differentiation and function of osteoclasts. SP-stimulated osteoclast formation is competitively regulated by peripheral HK-1 through NK1-Rs." @default.
• W2051217866 created "2016-06-24" @default.
• W2051217866 creator A5029259830 @default.
• W2051217866 creator A5030353236 @default.
• W2051217866 creator A5051977307 @default.
• W2051217866 creator A5071176111 @default.
• W2051217866 creator A5079912978 @default.
• W2051217866 creator A5083383844 @default.
• W2051217866 creator A5089532607 @default.
• W2051217866 date "2013-08-01" @default.
• W2051217866 modified "2023-10-16" @default.
• W2051217866 title "Hemokinin-1 competitively inhibits substance P-induced stimulation of osteoclast formation and function" @default.
• W2051217866 cites W1491269320 @default.
• W2051217866 cites W1530365051 @default.
• W2051217866 cites W1530868743 @default.
• W2051217866 cites W1836429653 @default.
• W2051217866 cites W1860985526 @default.
• W2051217866 cites W1974199545 @default.
• W2051217866 cites W1975331387 @default.
• W2051217866 cites W1978394249 @default.
• W2051217866 cites W1997127543 @default.
• W2051217866 cites W2003693146 @default.
• W2051217866 cites W2004508515 @default.
• W2051217866 cites W2005601955 @default.
• W2051217866 cites W2009248844 @default.
• W2051217866 cites W2022675831 @default.
• W2051217866 cites W2031659210 @default.
• W2051217866 cites W2033586513 @default.
• W2051217866 cites W2035245258 @default.
• W2051217866 cites W2048862160 @default.
• W2051217866 cites W2057586331 @default.
• W2051217866 cites W2066524898 @default.
• W2051217866 cites W2070118755 @default.
• W2051217866 cites W2071390025 @default.
• W2051217866 cites W2074722200 @default.
• W2051217866 cites W2076576843 @default.
• W2051217866 cites W2082093645 @default.
• W2051217866 cites W2088302578 @default.
• W2051217866 cites W2093691858 @default.
• W2051217866 cites W2100680849 @default.
• W2051217866 cites W2118749186 @default.
• W2051217866 cites W2130831747 @default.
• W2051217866 cites W2133138760 @default.
• W2051217866 cites W2142377427 @default.
• W2051217866 cites W2143825558 @default.
• W2051217866 cites W2146390263 @default.
• W2051217866 cites W2147792449 @default.
• W2051217866 cites W4211109351 @default.
• W2051217866 cites W4247936073 @default.
• W2051217866 cites W4253904760 @default.
• W2051217866 cites W67026584 @default.
• W2051217866 doi "https://doi.org/10.1016/j.npep.2013.04.001" @default.
• W2051217866 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23660339" @default.
• W2051217866 hasPublicationYear "2013" @default.
• W2051217866 type Work @default.
• W2051217866 sameAs 2051217866 @default.
• W2051217866 citedByCount "10" @default.
• W2051217866 countsByYear W20512178662014 @default.
• W2051217866 countsByYear W20512178662015 @default.
• W2051217866 countsByYear W20512178662016 @default.
• W2051217866 countsByYear W20512178662017 @default.
• W2051217866 countsByYear W20512178662020 @default.
• W2051217866 countsByYear W20512178662022 @default.
• W2051217866 crossrefType "journal-article" @default.
• W2051217866 hasAuthorship W2051217866A5029259830 @default.
• W2051217866 hasAuthorship W2051217866A5030353236 @default.
• W2051217866 hasAuthorship W2051217866A5051977307 @default.
• W2051217866 hasAuthorship W2051217866A5071176111 @default.
• W2051217866 hasAuthorship W2051217866A5079912978 @default.
• W2051217866 hasAuthorship W2051217866A5083383844 @default.
• W2051217866 hasAuthorship W2051217866A5089532607 @default.
• W2051217866 hasConcept C118303440 @default.
• W2051217866 hasConcept C126322002 @default.
• W2051217866 hasConcept C134018914 @default.
• W2051217866 hasConcept C150903083 @default.
• W2051217866 hasConcept C153911025 @default.
• W2051217866 hasConcept C169760540 @default.
• W2051217866 hasConcept C170493617 @default.
• W2051217866 hasConcept C185592680 @default.
• W2051217866 hasConcept C207001950 @default.
• W2051217866 hasConcept C2776033226 @default.
• W2051217866 hasConcept C2776352249 @default.
• W2051217866 hasConcept C2776533618 @default.
• W2051217866 hasConcept C2779428903 @default.
• W2051217866 hasConcept C2780007613 @default.
• W2051217866 hasConcept C71924100 @default.
• W2051217866 hasConcept C7876069 @default.
• W2051217866 hasConcept C86803240 @default.
• W2051217866 hasConcept C88045685 @default.
• W2051217866 hasConcept C94487597 @default.
• W2051217866 hasConceptScore W2051217866C118303440 @default.
• W2051217866 hasConceptScore W2051217866C126322002 @default.
• W2051217866 hasConceptScore W2051217866C134018914 @default.
• W2051217866 hasConceptScore W2051217866C150903083 @default.
• W2051217866 hasConceptScore W2051217866C153911025 @default.
• W2051217866 hasConceptScore W2051217866C169760540 @default.
• W2051217866 hasConceptScore W2051217866C170493617 @default.
• W2051217866 hasConceptScore W2051217866C185592680 @default.

• next