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- W2051218880 abstract "Mitragyna ciliata is commonly used in traditional medicine for the treatment of inflammation, hypertension, headache, rheumatism, gonorrhoea and broncho-pulmonary diseases. In the present study, the vascular relaxant effect in the rat and guinea-pig was investigated. The extract induced aortic relaxation in a concentration-dependent manner, with an EC(50) of 1.3 and 7 microg/mL for the noradrenaline- and KCl-induced contractions, respectively. The relaxant effect of the extract on KCl-induced contractions was fi ve times greater than on noradrenaline-induced contractions. Moreover, the relaxant effect of the extract was higher in rat aortic rings with endothelium (104.67%) than without endothelium (49.44%). Chemical analysis of the extract showed the presence of alkaloids and flavonoids which may be responsible for the antihypertensive properties." @default.
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- W2051218880 date "2004-01-01" @default.
- W2051218880 modified "2023-10-06" @default.
- W2051218880 title "Vasodilating properties of the stem bark extract ofMitragyna ciliata in rats and guinea pigs" @default.
- W2051218880 doi "https://doi.org/10.1002/ptr.1350" @default.
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