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- W2051219559 abstract "Long-lasting forms of neuronal plasticity require de novo gene expression, but relatively little is known about the events that occur genome-wide in response to activity in a neuronal network. Here, we unveil the gene expression programs initiated in mouse hippocampal neurons in response to different stimuli and explore the contribution of four prominent plasticity-related transcription factors (CREB, SRF, EGR1, and FOS) to these programs. Our study provides a comprehensive view of the intricate genetic networks and interactions elicited by neuronal stimulation identifying hundreds of novel downstream targets, including novel stimulus-associated miRNAs and candidate genes that may be differentially regulated at the exon/promoter level. Our analyses indicate that these four transcription factors impinge on similar biological processes through primarily non-overlapping gene-expression programs. Meta-analysis of the datasets generated in our study and comparison with publicly available transcriptomics data revealed the individual and collective contribution of these transcription factors to different activity-driven genetic programs. In addition, both gain- and loss-of-function experiments support a pivotal role for CREB in membrane-to-nucleus signal transduction in neurons. Our data provide a novel resource for researchers wanting to explore the genetic pathways associated with activity-regulated neuronal functions." @default.
- W2051219559 created "2016-06-24" @default.
- W2051219559 creator A5020496245 @default.
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- W2051219559 creator A5029601108 @default.
- W2051219559 creator A5042232111 @default.
- W2051219559 creator A5065717529 @default.
- W2051219559 date "2011-12-14" @default.
- W2051219559 modified "2023-10-01" @default.
- W2051219559 title "cAMP Response Element-Binding Protein Is a Primary Hub of Activity-Driven Neuronal Gene Expression" @default.
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- W2051219559 cites W1983861057 @default.
- W2051219559 cites W1989221124 @default.
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- W2051219559 doi "https://doi.org/10.1523/jneurosci.4554-11.2011" @default.
- W2051219559 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6623905" @default.
- W2051219559 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22171029" @default.
- W2051219559 hasPublicationYear "2011" @default.
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