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• W2051219862 abstract "K+ channels are known through electrophysiology and pharmacology to be an exceptionally diverse group of channels. Molecular studies of the Shaker (Sh) locus in Drosophila have provided the first glimpse of K+ channel structure. The sequences of several Sh cDNA clones have been reported; none are identical. We have isolated and examined 18 additional Sh cDNAs in an attempt to understand the origin, extent, and significance of the variability. The diversity is extensive: we have already identified cDNAs representing at least nine distinct types, and Sh could potentially encode 24 or more products. This diversity, however, fits a simple pattern in which variable 3' and 5' ends are spliced onto a central constant region to yield different cDNA types. These different Sh cDNAs encode proteins with distinct structural features." @default.
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• W2051219862 date "1988-07-01" @default.
• W2051219862 modified "2023-09-24" @default.
• W2051219862 title "Multiple products of the drosophila Shaker gene may contribute to potassium channel diversity" @default.
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• W2051219862 doi "https://doi.org/10.1016/0896-6273(88)90192-4" @default.
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