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• W2051220005 abstract "Upon activation, naive CD4 T cells differentiate into a variety of T-helper-cell subsets characterized by different cytokine production and functions. Currently, lineage commitment is considered to depend mostly on the environmental context to which naive CD4 T cells are exposed. Here we challenge this model based on the supposed homogeneity of the naive CD4 T-cell compartment. We show that peripheral naive CD4 T cells can be subdivided into two subsets according to Ly-6C expression. Furthermore, the two newly defined subsets (Ly-6C(-) and Ly-6C(+) naive CD4 T cells) are not equal in their intrinsic ability to commit into the induced regulatory T-cell lineage. Finally, phenotypic analysis, imaging and adoptive transfer experiments reveal that Ly-6C expression is modulated by self-recognition, allowing the dichotomization of the naive CD4 T-cell compartment into two cell subsets with distinct self-reactivity. Altogether, our results show that naive CD4 T cells with the highest avidity for self are prone to differentiate into regulatory T cells." @default.
• W2051220005 created "2016-06-24" @default.
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• W2051220005 date "2013-07-31" @default.
• W2051220005 modified "2023-10-13" @default.
• W2051220005 title "Highly self-reactive naive CD4 T cells are prone to differentiate into regulatory T cells" @default.
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• W2051220005 doi "https://doi.org/10.1038/ncomms3209" @default.
• W2051220005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23900386" @default.
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