FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051220082> ?p ?o ?g. }

• W2051220082 endingPage "2388" @default.
• W2051220082 startingPage "2383" @default.
• W2051220082 abstract "Hyperhomocysteinemia has been identified as a potential risk factor for atherosclerosis. This study examined whether a modest elevation of plasma total homocysteine (tHcy) was an independent risk factor for increased carotid artery intimal-medial wall thickness (IMT) and focal plaque formation in a large, randomly selected community population. We also examined whether vitamin cofactors and the C677T genetic mutation of the methylenetetrahydrofolate reductase (MTHFR) enzyme were major contributors to elevated plasma tHcy and carotid vascular disease.In 1111 subjects (558 men, 553 women) 52+/-13 years old (mean+/-SD; range, 27 to 77 years) recruited from a random electoral roll survey, we measured fasting tHcy and performed bilateral carotid B-mode ultrasound. For the total population, mean tHcy was 12.1+/-4.0 micromol/L. Plasma tHcy levels were correlated with IMT (Spearman rank rs=0.31, P=0.0001). After adjustment for age, sex, and other conventional risk factors, subjects in the highest versus the lowest quartile of tHcy had an odds ratio of 2.60 (95% CI, 1.51 to 4.45) for increased IMT and 1.76 (95% CI, 1.10 to 2.82) for plaque. Serum and dietary folate levels and the C677T mutation in MTHFR were independent determinants of tHcy (all P=0.0001). The mutant homozygotes (10% of the population) had higher mean tHcy than heterozygotes or those without the mutation (14.2 versus 12.3 versus 11.6 micromol/L, respectively, P=0.0001). The inverse association of folate levels with tHcy was steeper in the mutant homozygotes. Despite this, the C677T MTHFR mutation was not independently predictive of increased carotid IMT or plaque formation.Mild hyperhomocysteinemia is an independent risk factor for increased carotid artery wall thickness and plaque formation in a general population. Lower levels of dietary folate intake and the C677T mutation in MTHFR are important causes of mild hyperhomocysteinemia and may therefore contribute to vascular disease in the community." @default.
• W2051220082 created "2016-06-24" @default.
• W2051220082 creator A5037270250 @default.
• W2051220082 creator A5043042079 @default.
• W2051220082 creator A5043827664 @default.
• W2051220082 creator A5044964182 @default.
• W2051220082 creator A5089524422 @default.
• W2051220082 date "1999-05-11" @default.
• W2051220082 modified "2023-10-18" @default.
• W2051220082 title "Hyperhomocysteinemia but Not the C677T Mutation of Methylenetetrahydrofolate Reductase Is an Independent Risk Determinant of Carotid Wall Thickening" @default.
• W2051220082 cites W1975357252 @default.
• W2051220082 cites W1991143380 @default.
• W2051220082 cites W1995781460 @default.
• W2051220082 cites W2015612053 @default.
• W2051220082 cites W2024520632 @default.
• W2051220082 cites W2037565149 @default.
• W2051220082 cites W2068653999 @default.
• W2051220082 cites W2079159618 @default.
• W2051220082 cites W2080895280 @default.
• W2051220082 cites W2086045918 @default.
• W2051220082 cites W2116404316 @default.
• W2051220082 cites W2131343690 @default.
• W2051220082 cites W2146865335 @default.
• W2051220082 cites W2150523951 @default.
• W2051220082 cites W2165715420 @default.
• W2051220082 cites W2332685851 @default.
• W2051220082 doi "https://doi.org/10.1161/01.cir.99.18.2383" @default.
• W2051220082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10318658" @default.
• W2051220082 hasPublicationYear "1999" @default.
• W2051220082 type Work @default.
• W2051220082 sameAs 2051220082 @default.
• W2051220082 citedByCount "193" @default.
• W2051220082 countsByYear W20512200822012 @default.
• W2051220082 countsByYear W20512200822013 @default.
• W2051220082 countsByYear W20512200822014 @default.
• W2051220082 countsByYear W20512200822015 @default.
• W2051220082 countsByYear W20512200822016 @default.
• W2051220082 countsByYear W20512200822017 @default.
• W2051220082 countsByYear W20512200822018 @default.
• W2051220082 countsByYear W20512200822020 @default.
• W2051220082 countsByYear W20512200822021 @default.
• W2051220082 countsByYear W20512200822022 @default.
• W2051220082 countsByYear W20512200822023 @default.
• W2051220082 crossrefType "journal-article" @default.
• W2051220082 hasAuthorship W2051220082A5037270250 @default.
• W2051220082 hasAuthorship W2051220082A5043042079 @default.
• W2051220082 hasAuthorship W2051220082A5043827664 @default.
• W2051220082 hasAuthorship W2051220082A5044964182 @default.
• W2051220082 hasAuthorship W2051220082A5089524422 @default.
• W2051220082 hasBestOaLocation W20512200821 @default.
• W2051220082 hasConcept C104317684 @default.
• W2051220082 hasConcept C126322002 @default.
• W2051220082 hasConcept C134018914 @default.
• W2051220082 hasConcept C135763542 @default.
• W2051220082 hasConcept C156957248 @default.
• W2051220082 hasConcept C164705383 @default.
• W2051220082 hasConcept C2776523773 @default.
• W2051220082 hasConcept C2777090595 @default.
• W2051220082 hasConcept C2908647359 @default.
• W2051220082 hasConcept C43563269 @default.
• W2051220082 hasConcept C44249647 @default.
• W2051220082 hasConcept C50440223 @default.
• W2051220082 hasConcept C54355233 @default.
• W2051220082 hasConcept C68443243 @default.
• W2051220082 hasConcept C71924100 @default.
• W2051220082 hasConcept C86803240 @default.
• W2051220082 hasConcept C90924648 @default.
• W2051220082 hasConcept C99454951 @default.
• W2051220082 hasConceptScore W2051220082C104317684 @default.
• W2051220082 hasConceptScore W2051220082C126322002 @default.
• W2051220082 hasConceptScore W2051220082C134018914 @default.
• W2051220082 hasConceptScore W2051220082C135763542 @default.
• W2051220082 hasConceptScore W2051220082C156957248 @default.
• W2051220082 hasConceptScore W2051220082C164705383 @default.
• W2051220082 hasConceptScore W2051220082C2776523773 @default.
• W2051220082 hasConceptScore W2051220082C2777090595 @default.
• W2051220082 hasConceptScore W2051220082C2908647359 @default.
• W2051220082 hasConceptScore W2051220082C43563269 @default.
• W2051220082 hasConceptScore W2051220082C44249647 @default.
• W2051220082 hasConceptScore W2051220082C50440223 @default.
• W2051220082 hasConceptScore W2051220082C54355233 @default.
• W2051220082 hasConceptScore W2051220082C68443243 @default.
• W2051220082 hasConceptScore W2051220082C71924100 @default.
• W2051220082 hasConceptScore W2051220082C86803240 @default.
• W2051220082 hasConceptScore W2051220082C90924648 @default.
• W2051220082 hasConceptScore W2051220082C99454951 @default.
• W2051220082 hasIssue "18" @default.
• W2051220082 hasLocation W20512200821 @default.
• W2051220082 hasLocation W20512200822 @default.
• W2051220082 hasOpenAccess W2051220082 @default.
• W2051220082 hasPrimaryLocation W20512200821 @default.
• W2051220082 hasRelatedWork W1976692919 @default.
• W2051220082 hasRelatedWork W2007836117 @default.
• W2051220082 hasRelatedWork W2022182003 @default.
• W2051220082 hasRelatedWork W2101998653 @default.
• W2051220082 hasRelatedWork W2142601413 @default.
• W2051220082 hasRelatedWork W2403694630 @default.
• W2051220082 hasRelatedWork W2409516397 @default.

• next