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- W2051220404 abstract "Drug delivery vehicles that combine ultrasonic and molecular targeting are shown to locally concentrate a drug in a region-of-interest. The drug delivery vehicles, referred to as acoustically active lipospheres (AALs), are microbubbles surrounded by a shell of oil and lipid. In a region limited to the focal area of ultrasound application, circulating AALs are deflected by radiation force to a vessel wall and can subsequently be fragmented. Ligands targeting the αvβ3 integrin are conjugated to the AAL shell and increase in vitro binding by 26.5-fold over nontargeted agents. Toxicity assays demonstrate that paclitaxel-containing AALs exert a greater antiproliferative effect after insonation than free paclitaxel at an equivalent concentration. Lastly, ultrasound and molecular targeting are combined to deliver a model drug to the endothelium and interstitium of chorioallantoic membrane vasculature in vivo. (E-mail: [email protected] )" @default.
- W2051220404 created "2016-06-24" @default.
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- W2051220404 date "2006-11-01" @default.
- W2051220404 modified "2023-10-01" @default.
- W2051220404 title "Therapeutic effects of paclitaxel-containing ultrasound contrast agents" @default.
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- W2051220404 doi "https://doi.org/10.1016/j.ultrasmedbio.2006.03.017" @default.
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