Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051220419> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2051220419 endingPage "93" @default.
- W2051220419 startingPage "91" @default.
- W2051220419 abstract "The reported increase of infections of Plasmodium falciparum which are no longer susceptible to a combination of pyrimethamine and sulphadoxine--Fansidar--emphasizes the need for an in vitro test to determine the presence and prevalence of drug-resistant parasites. Studies with the pyrimethamine-sensitive FCB strain and the pyrimethamine-resistant FTA strain showed that the in vitro microtechnique can be used to determine differences in the susceptibility of these two strains to pyrimethamine and to pyrimethamine-sulphadoxine combinations. The FCB strain was almost six times more susceptible to pyrimethamine than the FTA strain. Although relatively high concentrations of sulphadoxine alone exerted no detectable antimalarial effects, the sulphonamide potentiated the activity of pyrimethamine against both strains of P. falciparum. This synergistic activity was relatively more pronounced against the pyrimethamine-resistant strain, particularly at lower concentrations of sulphadoxine. Further studies are indicated to determine to what extent findings obtained with the in vitro microtechnique can be correlated with the response of falciparum infection to treatment with pyrimethamine-sulphadoxine combinations." @default.
- W2051220419 created "2016-06-24" @default.
- W2051220419 creator A5003204240 @default.
- W2051220419 creator A5004230100 @default.
- W2051220419 date "1983-01-01" @default.
- W2051220419 modified "2023-09-27" @default.
- W2051220419 title "The activity of pyrimethamine and sulphadoxine against Plasmodium falciparum determined by the in vitro microtechnique" @default.
- W2051220419 cites W1969503178 @default.
- W2051220419 cites W1972126812 @default.
- W2051220419 cites W1990074634 @default.
- W2051220419 cites W2020251171 @default.
- W2051220419 cites W2042623378 @default.
- W2051220419 cites W2144017030 @default.
- W2051220419 cites W2336622083 @default.
- W2051220419 cites W2405392129 @default.
- W2051220419 doi "https://doi.org/10.1016/0035-9203(83)90026-3" @default.
- W2051220419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6344364" @default.
- W2051220419 hasPublicationYear "1983" @default.
- W2051220419 type Work @default.
- W2051220419 sameAs 2051220419 @default.
- W2051220419 citedByCount "10" @default.
- W2051220419 countsByYear W20512204192012 @default.
- W2051220419 countsByYear W20512204192018 @default.
- W2051220419 countsByYear W20512204192022 @default.
- W2051220419 crossrefType "journal-article" @default.
- W2051220419 hasAuthorship W2051220419A5003204240 @default.
- W2051220419 hasAuthorship W2051220419A5004230100 @default.
- W2051220419 hasConcept C159047783 @default.
- W2051220419 hasConcept C202751555 @default.
- W2051220419 hasConcept C203014093 @default.
- W2051220419 hasConcept C2777035104 @default.
- W2051220419 hasConcept C2778048844 @default.
- W2051220419 hasConcept C2778301690 @default.
- W2051220419 hasConcept C2778371730 @default.
- W2051220419 hasConcept C55493867 @default.
- W2051220419 hasConcept C86803240 @default.
- W2051220419 hasConcept C89423630 @default.
- W2051220419 hasConcept C98274493 @default.
- W2051220419 hasConceptScore W2051220419C159047783 @default.
- W2051220419 hasConceptScore W2051220419C202751555 @default.
- W2051220419 hasConceptScore W2051220419C203014093 @default.
- W2051220419 hasConceptScore W2051220419C2777035104 @default.
- W2051220419 hasConceptScore W2051220419C2778048844 @default.
- W2051220419 hasConceptScore W2051220419C2778301690 @default.
- W2051220419 hasConceptScore W2051220419C2778371730 @default.
- W2051220419 hasConceptScore W2051220419C55493867 @default.
- W2051220419 hasConceptScore W2051220419C86803240 @default.
- W2051220419 hasConceptScore W2051220419C89423630 @default.
- W2051220419 hasConceptScore W2051220419C98274493 @default.
- W2051220419 hasIssue "1" @default.
- W2051220419 hasLocation W20512204191 @default.
- W2051220419 hasLocation W20512204192 @default.
- W2051220419 hasOpenAccess W2051220419 @default.
- W2051220419 hasPrimaryLocation W20512204191 @default.
- W2051220419 hasRelatedWork W1746729210 @default.
- W2051220419 hasRelatedWork W1969218147 @default.
- W2051220419 hasRelatedWork W2000038263 @default.
- W2051220419 hasRelatedWork W2013263702 @default.
- W2051220419 hasRelatedWork W2022025781 @default.
- W2051220419 hasRelatedWork W2065689323 @default.
- W2051220419 hasRelatedWork W2255592049 @default.
- W2051220419 hasRelatedWork W2346508301 @default.
- W2051220419 hasRelatedWork W2506425667 @default.
- W2051220419 hasRelatedWork W4214954457 @default.
- W2051220419 hasVolume "77" @default.
- W2051220419 isParatext "false" @default.
- W2051220419 isRetracted "false" @default.
- W2051220419 magId "2051220419" @default.
- W2051220419 workType "article" @default.