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- W2051220949 abstract "Arterial blood hydrogen ion concentration (Ha+) was altered over the range of 25 to 110 nM (pH 7.60 to 6.96) by slow intravenous infusion of 1.0 N NaHCO3 or 0.5 N HCl at controlled levels of Paco2 in unanesthetized decerebrate cats. Respiratory f varied as a single function of VT irrespective of alterations in Paco2 and Ha even after interruption of the carotid sinus nerves. The dependence of f upon vt was abolished by vagotomy. However, Vt continued to respond to changes in Ha over its entire range after combined section of the vagus and carotid sinus nerves. In all states of peripheral innervation, the ΔVtΔHa+ response to inhalation of CO2 exceeded by 5 to 10 times the ΔVt/ΔHa+ response to acid or bicarbonate infused under isocapnic control. Increases and decreases of Hat caused downward and upward shifts. respectively, in the operating setpoint of the CO2 regulation system." @default.
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- W2051220949 date "1977-08-01" @default.
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- W2051220949 title "Arterial hydrogen ion versus CO2 on depth and rate of breathing in decerebrate cats" @default.
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- W2051220949 doi "https://doi.org/10.1016/0034-5687(77)90038-x" @default.
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