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- W2051222028 abstract "Abstract The effects of repeated administration of small doses of l -lysergic acid diethylamide (LSD) on brainstem norepinephrine (NE), serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), tyrosine, tryptophan, tyrosine hydroxylase and tryptophan hydroxylase have been studied in male Sprague-Dawley rats. A daily dose of 20 μm/kg given for 14 days resulted in a significantly lowered NE level and tyrosine hydroxylase activity measured 24 hr after the last injection. Treatment with 100 ifμm/kg/day for the same period of time produced similar changes together with a significantly lower brainstem tyrosine content. Evidence was obtained that the NE turnover in rat brainstem was significantly increased at the higher dose level only. The lower dose of 20 μm/kg/day also resulted in an elevated 5-HT and lowered 5-HIAA content. However, when the dose was increased to 100 μm/kg/day the 5-HT content was unchanged and the 5-HIAA content increased. The 5-HT turnover was reduced when the rats were treated with 20 μm/kg/day but significantly elevated when the 100-μm dose was used." @default.
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- W2051222028 date "1974-01-01" @default.
- W2051222028 modified "2023-09-26" @default.
- W2051222028 title "Comparison of the chronic and acute effects of d-Lysergic Acid Diethylamide (LSD) treatment on rat brain serotonin and norepinephrine" @default.
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- W2051222028 doi "https://doi.org/10.1016/0006-2952(74)90414-6" @default.
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