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- W2051222207 abstract "Hypovitaminotic C guinea pigs fed a high cholesterol diet for 5 weeks developed gallstones (81% cholesterol by weight), whereas no concretements were observed in vitamin C replete animals fed the same diet. Gallstone formation was associated with qualitative changes in the gallbladder bile, namely, a higher cholesterol concentration, a lowered bile acid content, and diminished phospholipid: cholesterol and bile acid: cholesterol ratios. No differences in 7α-ketolithocholic acid levels between groups was observed, but the chronic hypovitaminotic C animals had significantly lower levels of chenodeoxycholic acid. It is concluded that in the chronically hypotivaminotic C guinea pig there is a reduction in gallbladder bile acid: cholesterol and phospholipid; cholesterol ratios arising from an impaired conversion of cholesterol to chenodeoxycholic acid, and that consequently cholesterol precipitation and gallstone formation are favoured." @default.
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- W2051222207 date "1977-08-01" @default.
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- W2051222207 title "Hypovitaminosis C and cholelithiasis in guinea pigs" @default.
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- W2051222207 doi "https://doi.org/10.1016/s0006-291x(77)80081-8" @default.
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