FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051223523> ?p ?o ?g. }

• W2051223523 endingPage "501" @default.
• W2051223523 startingPage "501" @default.
• W2051223523 abstract "This issue of The Journal of Physiology contains a paper by Mogensen et al (2006) that is an excellent example of integrative physiology, addressing questions both at the subcellular and whole body levels that have implications for basic muscle energetics as well as athletic performance. Within a given population, muscular efficiency and thus work rate typically vary by as much as 20–30% when comparing individuals with low vs. high efficiency individuals despite controlling for oxygen consumption, training status, diet and other factors (Coyle et al. 1992). This represents a large amount of biological difference between individuals, which directly influences physical stress and work productivity. Elucidating the factors that determine and influence the energetic efficiency of human muscular movement in vivo, as currently measured by cycling or work efficiency, remains an important, open and challenging question.Work efficiency represents the product of two phenomena: (a) the efficiency with which the chemical energy of glucose and/or fat is converted to ATP through oxidative phosphorylation; and (b) the efficiency with which the chemical energy of ATP hydrolysis is converted to work. Mogensen et al (2006) convincingly demonstrate that differences in the efficiency of human muscular movement (e.g. gross cycling efficiency) observed among people cannot be explained by their in vitro differences in efficiency of oxidative phosphorylation within leg muscle mitochondria. Furthermore, mitochondrial efficiency was not different in endurance trained versus untrained individuals. This implies that the large differences among individuals in cycling efficiency appear to be due largely to the efficiency of transferring the chemical energy from ATP hydrolysis into physical work.The authors provide a good road map for translational physiologists to follow, especially when, as in the present case, the results don't support the initial hypothesis. Contrary to the initial hypothesis, cycling efficiency of people in vivo was not related to mitochondrial respiratory efficiency (i.e. phosphorylation ratio; P/O ratio) measured in vitro within isolated skeletal muscle mitochondria. The authors display keen insight into the literature and wisdom as they reconstruct how molecules of UCP3 or myosin might translate into the muscle functions currently observed. These appear to be the first such measurements made in vitro on humans of skeletal muscle mitochondrial efficiency measured during submaximal respiration. For this purpose, the authors developed a physiologically appropriate method involving constant rate ADP infusion across multiple flux rates to calculated the P/O at a common 50% value. However, their hard earned and physiologically sound data failed to support their theory leading to a host of new questions.The main new finding in the present study was that cycling efficiency was correlated to UCP3 protein content. It is hypothesized that other factors such as muscle fibre type influence UCP3 and thus muscle efficiency in vivo. However, the authors recognize the limitations in concluding a cause and effect relationship between UCP3 protein content and efficiency and go on to present a balanced argument including discussion against a direct role of UCP3 in determining muscle efficiency. This study again shows that cross-sectional endurance training status does not relate to mitochondrial efficiency (Tonkonogi et al. 2000; Fernstrom et al. 2004).Although oxidative phosphorylation can have direct influence on cycling efficiency, the authors acknowledge that it represents only part of the equation for work or cycling efficiency. We are left with an emerging picture that cycling efficiency appears related to percentage MHC I and somehow to UCP3 protein content. This study has made clear the fact that solving this puzzle requires use of techniques at the molecular and whole body levels, both of which can only be interpreted when controlling for the relative work rate." @default.
• W2051223523 created "2016-06-24" @default.
• W2051223523 creator A5034844182 @default.
• W2051223523 date "2006-03-01" @default.
• W2051223523 modified "2023-09-23" @default.
• W2051223523 title "Understanding efficiency of human muscular movement exemplifies integrative and translational physiology" @default.
• W2051223523 cites W2016378441 @default.
• W2051223523 cites W2080760844 @default.
• W2051223523 cites W2105580366 @default.
• W2051223523 cites W2136397032 @default.
• W2051223523 doi "https://doi.org/10.1113/jphysiol.2006.106591" @default.
• W2051223523 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1805800" @default.
• W2051223523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16469776" @default.
• W2051223523 hasPublicationYear "2006" @default.
• W2051223523 type Work @default.
• W2051223523 sameAs 2051223523 @default.
• W2051223523 citedByCount "5" @default.
• W2051223523 countsByYear W20512235232013 @default.
• W2051223523 countsByYear W20512235232021 @default.
• W2051223523 crossrefType "journal-article" @default.
• W2051223523 hasAuthorship W2051223523A5034844182 @default.
• W2051223523 hasBestOaLocation W20512235231 @default.
• W2051223523 hasConcept C127413603 @default.
• W2051223523 hasConcept C166957645 @default.
• W2051223523 hasConcept C18762648 @default.
• W2051223523 hasConcept C18903297 @default.
• W2051223523 hasConcept C2742236 @default.
• W2051223523 hasConcept C2908647359 @default.
• W2051223523 hasConcept C42407357 @default.
• W2051223523 hasConcept C541528975 @default.
• W2051223523 hasConcept C55493867 @default.
• W2051223523 hasConcept C57600042 @default.
• W2051223523 hasConcept C71924100 @default.
• W2051223523 hasConcept C78519656 @default.
• W2051223523 hasConcept C86803240 @default.
• W2051223523 hasConcept C95457728 @default.
• W2051223523 hasConcept C99454951 @default.
• W2051223523 hasConceptScore W2051223523C127413603 @default.
• W2051223523 hasConceptScore W2051223523C166957645 @default.
• W2051223523 hasConceptScore W2051223523C18762648 @default.
• W2051223523 hasConceptScore W2051223523C18903297 @default.
• W2051223523 hasConceptScore W2051223523C2742236 @default.
• W2051223523 hasConceptScore W2051223523C2908647359 @default.
• W2051223523 hasConceptScore W2051223523C42407357 @default.
• W2051223523 hasConceptScore W2051223523C541528975 @default.
• W2051223523 hasConceptScore W2051223523C55493867 @default.
• W2051223523 hasConceptScore W2051223523C57600042 @default.
• W2051223523 hasConceptScore W2051223523C71924100 @default.
• W2051223523 hasConceptScore W2051223523C78519656 @default.
• W2051223523 hasConceptScore W2051223523C86803240 @default.
• W2051223523 hasConceptScore W2051223523C95457728 @default.
• W2051223523 hasConceptScore W2051223523C99454951 @default.
• W2051223523 hasIssue "3" @default.
• W2051223523 hasLocation W20512235231 @default.
• W2051223523 hasLocation W20512235232 @default.
• W2051223523 hasLocation W20512235233 @default.
• W2051223523 hasOpenAccess W2051223523 @default.
• W2051223523 hasPrimaryLocation W20512235231 @default.
• W2051223523 hasRelatedWork W2037488870 @default.
• W2051223523 hasRelatedWork W2055450638 @default.
• W2051223523 hasRelatedWork W2090311295 @default.
• W2051223523 hasRelatedWork W2116607620 @default.
• W2051223523 hasRelatedWork W2255890660 @default.
• W2051223523 hasRelatedWork W2356037272 @default.
• W2051223523 hasRelatedWork W2512590240 @default.
• W2051223523 hasRelatedWork W2516654687 @default.
• W2051223523 hasRelatedWork W2554880752 @default.
• W2051223523 hasRelatedWork W2914639108 @default.
• W2051223523 hasVolume "571" @default.
• W2051223523 isParatext "false" @default.
• W2051223523 isRetracted "false" @default.
• W2051223523 magId "2051223523" @default.
• W2051223523 workType "article" @default.