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• W2051223706 abstract "The nature of the genetic restriction of T cell-macrophage interaction in helper cell induction has been investigated. By incubating F1 hybrid T cells with keyhole limpet hemocyanin and macrophages of one parental haplotype, helper cells were generated that cooperated with B cells of either parental haplotype, provided macrophages of the haplotype used for the initial priming were present in the cooperative culture. The experiment is in line with the view that F1 T cells reactive to a given antigen contain at least two independent clones, each responsive to antigen recognized in conjunction with macrophages of one parental strain, and moreover, indicates that genetic restriction of T cell-macrophage interaction may be induced by priming. However, by using F1 T cells it is not possible to exclude that restriction is already manifest prior to priming. Thus, experiments were performed using T cells from chimeric mice instead of F1 mice. Chimeric mice, prepared by injecting lethally irradiated F1 mice with anti-θ-treated bone marrow cells of both parental types, have two histoincompatible lymphoid pools which are mutually tolerant. T cells of one type, prepared by treatment with anti H-2 serum and complement, were not able to interact with macrophages of the other histoincompatible parental type indicating that genetic restrictions in interaction may be expressed prior to antigenic stimulation. The possibility that suppression is the mechanism of the restriction of T cell-macrophage interaction in helper cell induction has been investigated and excluded, based on several lines of evidence. First, genetic restriction is not broken by treatment of helper cells induced by allogeneic genetically related macrophage factors (GRF) (or mixtures of syngeneic and allogeneic GRF) with antisera which kill suppressor cells, which may have masked the help induced with allogeneic GRF. Second, chimeric mice, which have not been shown to have suppressor cells, still show the same genetic restriction. The implication of these findings for patterns of T cell recognition is discussed." @default.
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• W2051223706 title "Nature of T cell-macrophage interaction in helper cell inductionin vitro I. Evidence for genetic restriction of T cell-macrophage interactions prior to T cell priming" @default.
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• W2051223706 doi "https://doi.org/10.1002/eji.1830081107" @default.
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