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- W2051223707 abstract "Abnormal stretch and strain is a major cause of injury to the spinal cord and brainstem. Such forces can develop fromage-related degeneration, congenital malformations, occupational exposure, or trauma such as sporting accidents,whiplash and blast injury. While current imaging technologies provide excellent morphology and anatomy of the spinalcord, there is no validated diagnostic tool to assess mechanical stresses exerted upon the spinal cord and brainstem.Furthermore, there is no current means to correlate these stress patterns with known spinal cord injuries and otherclinical metrics such as neurological impairment. We have therefore developed the spinal cord stress injury assessment(SCOSIA) system, which uses imaging and finite element analysis to predict stretch injury. This system was tested on asmall cohort of neurosurgery patients. Initial results show that the calculated stress values decreased following surgery,and that this decrease was accompanied by a significant decrease in neurological symptoms. Regression analysisidentified modest correlations between stress values and clinical metrics. The strongest correlations were seen with theBrainstem Disability Index (BDI) and the Karnofsky Performance Score (KPS), whereas the weakest correlations wereseen with the American Spinal Injury Association (ASIA) scale. SCOSIA therefore shows encouraging initial resultsand may have wide applicability to trauma and degenerative disease involving the spinal cord and brainstem." @default.
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- W2051223707 date "2009-02-26" @default.
- W2051223707 modified "2023-09-23" @default.
- W2051223707 title "Spinal cord stress injury assessment (SCOSIA): clinical applications of mechanical modeling of the spinal cord and brainstem" @default.
- W2051223707 doi "https://doi.org/10.1117/12.813791" @default.
- W2051223707 hasPublicationYear "2009" @default.
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