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• W2051224117 abstract "The interaction between l-Arg and calf thymus DNA (ctDNA) in sodium acetate–acetic acid buffer (pH = 4) was investigated with the use of neutral red (NR) dye as a spectral probe coupled with UV–vis absorption, fluorescence, and circular dichroism (CD) spectroscopy technique. The UV absorption spectroscopy indicated that l-Arg interacted with ctDNA via electrostatic force and the fluorescence enhancing of the DNA–NR system verified the electrostatic interaction. In addition, detectable changes in the CD spectrum of ctDNA in the presence of l-Arg indicated conformational changes in the DNA double helix after interaction with the drug. Docking studies were found to corroborate the experimental results. All these results prove that this drug interacts with ctDNA via an electrostatic binding mode." @default.
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• W2051224117 creator A5018173287 @default.
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• W2051224117 date "2012-11-01" @default.
• W2051224117 modified "2023-09-27" @default.
• W2051224117 title "Interactions of l-Arg with calf thymus DNA using neutral red dye as a fluorescence probe" @default.
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• W2051224117 doi "https://doi.org/10.1016/j.saa.2012.06.027" @default.
• W2051224117 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22842133" @default.
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