FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051224672> ?p ?o ?g. }

• W2051224672 endingPage "723" @default.
• W2051224672 startingPage "715" @default.
• W2051224672 abstract "The computational models for predicting oral drug absorption in humans using in vitro and in vivo data have been published. However, only a limited number of studies are available on the prediction of local drug efficacy in the mouth using computational models.The goal of this study was to develop a simulation model for prediction of drug amount and effect on carcinogenic acetaldehyde in the mouth.The model was based partly on our previous studies in which we showed in vivo that l-cysteine-containing tablets can eliminate carcinogenic salivary acetaldehyde in the mouth during smoking. To develop as informative a model as possible, we also investigated whether a lower saliva pH (4.7) can affect the freely soluble l-cysteine dissolution rate and cysteine stability profile in the mouth, compared to the normal saliva pH of 7.4.Stability of the active drug is not pH dependent and thus users with normal, healthy saliva pH and those with lower pH can benefit from cysteine-containing products. The simulated saliva profiles of l-cysteine and acetaldehyde corresponded to the in vivo results.The model developed can be used as an alternative tool to obtain faster and cheaper answers on how freely soluble drugs affect local conditions in the mouth. Because tobacco smoke contains more than 60 carcinogenic compounds, the model developed can offer a new view in eliminating or reducing not only one toxic compound from smoke but also many others compounds using only one formulation containing various active compounds." @default.
• W2051224672 created "2016-06-24" @default.
• W2051224672 creator A5000049713 @default.
• W2051224672 creator A5005365362 @default.
• W2051224672 creator A5028741585 @default.
• W2051224672 creator A5051566246 @default.
• W2051224672 creator A5086074709 @default.
• W2051224672 date "2010-02-06" @default.
• W2051224672 modified "2023-10-06" @default.
• W2051224672 title "Computational prediction of local drug effect on carcinogenic acetaldehyde in the mouth based on in vitro/in vivo results of freely soluble<scp>l</scp>-cysteine" @default.
• W2051224672 cites W1454743650 @default.
• W2051224672 cites W1490632139 @default.
• W2051224672 cites W1969157563 @default.
• W2051224672 cites W1982585538 @default.
• W2051224672 cites W1997744610 @default.
• W2051224672 cites W2002760231 @default.
• W2051224672 cites W2006630651 @default.
• W2051224672 cites W2015323657 @default.
• W2051224672 cites W2015439829 @default.
• W2051224672 cites W2018400887 @default.
• W2051224672 cites W2019038455 @default.
• W2051224672 cites W2024012503 @default.
• W2051224672 cites W2030813390 @default.
• W2051224672 cites W2039520265 @default.
• W2051224672 cites W2055744843 @default.
• W2051224672 cites W2059275644 @default.
• W2051224672 cites W2060823027 @default.
• W2051224672 cites W2072944219 @default.
• W2051224672 cites W2074354050 @default.
• W2051224672 cites W2080068747 @default.
• W2051224672 cites W2084515830 @default.
• W2051224672 cites W2093500966 @default.
• W2051224672 cites W2094252130 @default.
• W2051224672 cites W2100078320 @default.
• W2051224672 cites W2146653575 @default.
• W2051224672 cites W2163238154 @default.
• W2051224672 doi "https://doi.org/10.3109/03639040903456519" @default.
• W2051224672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20136487" @default.
• W2051224672 hasPublicationYear "2010" @default.
• W2051224672 type Work @default.
• W2051224672 sameAs 2051224672 @default.
• W2051224672 citedByCount "5" @default.
• W2051224672 countsByYear W20512246722012 @default.
• W2051224672 countsByYear W20512246722014 @default.
• W2051224672 countsByYear W20512246722017 @default.
• W2051224672 crossrefType "journal-article" @default.
• W2051224672 hasAuthorship W2051224672A5000049713 @default.
• W2051224672 hasAuthorship W2051224672A5005365362 @default.
• W2051224672 hasAuthorship W2051224672A5028741585 @default.
• W2051224672 hasAuthorship W2051224672A5051566246 @default.
• W2051224672 hasAuthorship W2051224672A5086074709 @default.
• W2051224672 hasConcept C114246631 @default.
• W2051224672 hasConcept C150903083 @default.
• W2051224672 hasConcept C181199279 @default.
• W2051224672 hasConcept C181389837 @default.
• W2051224672 hasConcept C185592680 @default.
• W2051224672 hasConcept C202751555 @default.
• W2051224672 hasConcept C207001950 @default.
• W2051224672 hasConcept C2777595113 @default.
• W2051224672 hasConcept C2779201268 @default.
• W2051224672 hasConcept C2780035454 @default.
• W2051224672 hasConcept C2780161600 @default.
• W2051224672 hasConcept C504460877 @default.
• W2051224672 hasConcept C55493867 @default.
• W2051224672 hasConcept C71924100 @default.
• W2051224672 hasConcept C86803240 @default.
• W2051224672 hasConcept C98274493 @default.
• W2051224672 hasConceptScore W2051224672C114246631 @default.
• W2051224672 hasConceptScore W2051224672C150903083 @default.
• W2051224672 hasConceptScore W2051224672C181199279 @default.
• W2051224672 hasConceptScore W2051224672C181389837 @default.
• W2051224672 hasConceptScore W2051224672C185592680 @default.
• W2051224672 hasConceptScore W2051224672C202751555 @default.
• W2051224672 hasConceptScore W2051224672C207001950 @default.
• W2051224672 hasConceptScore W2051224672C2777595113 @default.
• W2051224672 hasConceptScore W2051224672C2779201268 @default.
• W2051224672 hasConceptScore W2051224672C2780035454 @default.
• W2051224672 hasConceptScore W2051224672C2780161600 @default.
• W2051224672 hasConceptScore W2051224672C504460877 @default.
• W2051224672 hasConceptScore W2051224672C55493867 @default.
• W2051224672 hasConceptScore W2051224672C71924100 @default.
• W2051224672 hasConceptScore W2051224672C86803240 @default.
• W2051224672 hasConceptScore W2051224672C98274493 @default.
• W2051224672 hasIssue "6" @default.
• W2051224672 hasLocation W20512246721 @default.
• W2051224672 hasLocation W20512246722 @default.
• W2051224672 hasOpenAccess W2051224672 @default.
• W2051224672 hasPrimaryLocation W20512246721 @default.
• W2051224672 hasRelatedWork W1983433776 @default.
• W2051224672 hasRelatedWork W2030384680 @default.
• W2051224672 hasRelatedWork W2055360318 @default.
• W2051224672 hasRelatedWork W2088681451 @default.
• W2051224672 hasRelatedWork W2143170156 @default.
• W2051224672 hasRelatedWork W2245895065 @default.
• W2051224672 hasRelatedWork W2366418472 @default.
• W2051224672 hasRelatedWork W2390817463 @default.
• W2051224672 hasRelatedWork W2395978267 @default.
• W2051224672 hasRelatedWork W2415853889 @default.

• next