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• W2051225964 abstract "Reported here is an analytical method enabling the stereochemical resolution of a new antianginal compound possessing two stereogenic centers, leading to four stereoisomers. Only one of these isomers is currently under development as a novel antianginal agent and consequently, the other three isomers are considered as unwanted chiral impurities. Therefore, an enantioselective method is required in order to check its enantiomeric purity. This paper presents a method exploiting the high efficiency of capillary electrophoresis and the complexing properties of cyclodextrins to achieve the separation of the four stereoisomers of this weakly basic compound (pKa = 7.4). For this purpose, the combination of a neutral cyclodextrin, hydroxypropyl-γ-cyclodextrin (HP-γ-CD), and an anionic cyclodextrin, carboxymethyl-β-cyclodextrin (CM-β-CD), was added to the separation buffer running in an uncoated silica capillary. After selection of the suitable cyclodextrin system, satisfactorily separation conditions were as follows: 30 mM phosphate buffer (pH 6.4) containing 10 mM of HP-γ-CD and 10 mM of CM-β-CD, running voltage +30 kV. The resulting run time and resolutions were respectively about 17 min and between 1.95 and 2.84. Linearity curves (0.993 < r 2 < 0.998) are also shown." @default.
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• W2051225964 date "2005-04-01" @default.
• W2051225964 modified "2023-09-25" @default.
• W2051225964 title "Chiral separation of the four stereoisomers of a novel antianginal agent using a dual cyclodextrin system in capillary electrophoresis" @default.
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• W2051225964 doi "https://doi.org/10.1002/jssc.200400097" @default.
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