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- W2051226585 startingPage "997" @default.
- W2051226585 abstract "Presenilin is a central, catalytic component of the γ-secretase complex which conducts intramembrane cleavage of various protein substrates. Although identified and mainly studied through its role in the development of amyloid plaques in Alzheimer disease, γ-secretase has many other important functions. The complex seems to be evolutionary conserved throughout the Metazoa, but recent findings in plants and Dictyostelium discoideum as well as in archeons suggest that its evolution and functions might be much more diversified than previously expected. In this review, a selective survey of the multitude of functions of presenilins and the γ-secretase complex is presented. Following a brief overview of γ-secretase structure, assembly and maturation, three functional aspects are analyzed: (1) the role of γ-secretase in autophagy and phagocytosis; (2) involvement of the complex in signaling related to endocytosis; and (3) control of calcium fluxes by presenilins." @default.
- W2051226585 created "2016-06-24" @default.
- W2051226585 creator A5013745057 @default.
- W2051226585 creator A5032518022 @default.
- W2051226585 creator A5090077729 @default.
- W2051226585 date "2013-03-16" @default.
- W2051226585 modified "2023-10-16" @default.
- W2051226585 title "The very many faces of presenilins and the γ-secretase complex" @default.
- W2051226585 cites W1482745057 @default.
- W2051226585 cites W1495136850 @default.
- W2051226585 cites W1499189326 @default.
- W2051226585 cites W1499973238 @default.
- W2051226585 cites W1540368379 @default.
- W2051226585 cites W1572225000 @default.
- W2051226585 cites W1589286696 @default.
- W2051226585 cites W1626267121 @default.
- W2051226585 cites W1641838791 @default.
- W2051226585 cites W1675105744 @default.
- W2051226585 cites W1681258590 @default.
- W2051226585 cites W1812970642 @default.
- W2051226585 cites W1885312956 @default.
- W2051226585 cites W1886532866 @default.
- W2051226585 cites W1942857978 @default.
- W2051226585 cites W1960764034 @default.
- W2051226585 cites W1965123366 @default.
- W2051226585 cites W1966311581 @default.
- W2051226585 cites W1966398860 @default.
- W2051226585 cites W1967102740 @default.
- W2051226585 cites W1967785399 @default.
- W2051226585 cites W1968069499 @default.
- W2051226585 cites W1969071483 @default.
- W2051226585 cites W1969389122 @default.
- W2051226585 cites W1970041733 @default.
- W2051226585 cites W1970683213 @default.
- W2051226585 cites W1970925409 @default.
- W2051226585 cites W1972706019 @default.
- W2051226585 cites W1973939238 @default.
- W2051226585 cites W1974430916 @default.
- W2051226585 cites W1974768040 @default.
- W2051226585 cites W1975492746 @default.
- W2051226585 cites W1975600949 @default.
- W2051226585 cites W1975907645 @default.
- W2051226585 cites W1976240009 @default.
- W2051226585 cites W1977956545 @default.
- W2051226585 cites W1977962361 @default.
- W2051226585 cites W1978315349 @default.
- W2051226585 cites W1978510853 @default.
- W2051226585 cites W1978560720 @default.
- W2051226585 cites W1979274827 @default.
- W2051226585 cites W1981816482 @default.
- W2051226585 cites W1981860609 @default.
- W2051226585 cites W1983215567 @default.
- W2051226585 cites W1983867285 @default.
- W2051226585 cites W1985143687 @default.
- W2051226585 cites W1985341683 @default.
- W2051226585 cites W1987846066 @default.
- W2051226585 cites W1988646383 @default.
- W2051226585 cites W1991518782 @default.
- W2051226585 cites W1992907194 @default.
- W2051226585 cites W1993722622 @default.
- W2051226585 cites W1995839809 @default.
- W2051226585 cites W1996545500 @default.
- W2051226585 cites W1997366047 @default.
- W2051226585 cites W1998471281 @default.
- W2051226585 cites W2000075190 @default.
- W2051226585 cites W2004465970 @default.
- W2051226585 cites W2006257247 @default.
- W2051226585 cites W2006339817 @default.
- W2051226585 cites W2010550564 @default.
- W2051226585 cites W2011465322 @default.
- W2051226585 cites W2011905203 @default.
- W2051226585 cites W2012462249 @default.
- W2051226585 cites W2013306109 @default.
- W2051226585 cites W2013782136 @default.
- W2051226585 cites W2015798402 @default.
- W2051226585 cites W2016099927 @default.
- W2051226585 cites W2016807756 @default.
- W2051226585 cites W2017423460 @default.
- W2051226585 cites W2019556396 @default.
- W2051226585 cites W2020063796 @default.
- W2051226585 cites W2020365348 @default.
- W2051226585 cites W2022114463 @default.
- W2051226585 cites W2023188066 @default.
- W2051226585 cites W2023628337 @default.
- W2051226585 cites W2025560299 @default.
- W2051226585 cites W2026596383 @default.
- W2051226585 cites W2029298729 @default.
- W2051226585 cites W2030650261 @default.
- W2051226585 cites W2032232498 @default.
- W2051226585 cites W2032419750 @default.
- W2051226585 cites W2035587810 @default.
- W2051226585 cites W2036311400 @default.
- W2051226585 cites W2039607936 @default.
- W2051226585 cites W2040093488 @default.
- W2051226585 cites W2041108499 @default.
- W2051226585 cites W2043741577 @default.
- W2051226585 cites W2044227207 @default.
- W2051226585 cites W2045106215 @default.