FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051227944> ?p ?o ?g. }

• W2051227944 abstract "Enhanced in vitro chromosomal radiosensitivity (CRS) has been proposed as a marker for low-penetrance gene mutations predisposing to breast cancer (BC). Since the double strand break (DSB) is the most detrimental form of DNA damage induced by ionizing radiation, it is possible that mutations in genes encoding proteins involved in DSB repair affect breast cancer risk. The purpose of the present study was to examine whether five single nucleotide polymorphisms (SNPs) in Rad51 and Xrcc3 (rs1801320, rs1801321, rs1799796, rs861539 and rs1799794) exhibited an association with breast cancer susceptibility in a Belgian population of BC patients with a known or putative genetic predisposition. We also ascertained whether a relationship exists between the occurrence of the variant alleles of these variations and in vitro CRS. Blood samples were obtained from BC patients and from the control population that included healthy female individuals. Variations in the 5' UTR of Rad51 and Xrcc3 were genotyped, and statistical analysis was performed. The results showed that low-penetrant variations in Rad51 and Xrcc3, two proteins belonging to the homologous recombination DSB repair pathway, may modify BC risk in patients already carrying a pathological mutation in the highly penetrant BC genes BRCA1 and BRCA2. Combined risk genotype analysis revealed that Rad51 SNPs enhance BC risk in BRCA2 patients, whereas Xrcc3 SNPs significantly enhance BC risk in carriers of BRCA1 mutations and in patients with hereditary BC. When four putative risk genotypes of Rad51 and Xrcc3 were combined, positive significant odds ratios were obtained in the entire patient population and in patients with a hereditary history of disease. Although obtained from a limited number of patients, our data are supportive of a polygenic model whereby combinations of weak variations are responsible for an enhanced BC risk by acting jointly with high-penetrant mutations in BRCA1 or BRCA2." @default.
• W2051227944 created "2016-06-24" @default.
• W2051227944 creator A5002172316 @default.
• W2051227944 creator A5002741156 @default.
• W2051227944 creator A5028526077 @default.
• W2051227944 creator A5036354373 @default.
• W2051227944 creator A5037656636 @default.
• W2051227944 creator A5057368279 @default.
• W2051227944 creator A5060808021 @default.
• W2051227944 date "2011-07-01" @default.
• W2051227944 modified "2023-09-27" @default.
• W2051227944 title "Combined effect of polymorphisms in Rad51 and Xrcc3 on breast cancer risk and chromosomal radiosensitivity" @default.
• W2051227944 cites W1490473615 @default.
• W2051227944 cites W1595797072 @default.
• W2051227944 cites W1964256573 @default.
• W2051227944 cites W1965130491 @default.
• W2051227944 cites W1974730203 @default.
• W2051227944 cites W1980130932 @default.
• W2051227944 cites W1984919526 @default.
• W2051227944 cites W1994500609 @default.
• W2051227944 cites W1995077573 @default.
• W2051227944 cites W1998696381 @default.
• W2051227944 cites W2001749347 @default.
• W2051227944 cites W2004167207 @default.
• W2051227944 cites W2005580108 @default.
• W2051227944 cites W2006039428 @default.
• W2051227944 cites W2006781024 @default.
• W2051227944 cites W2010335397 @default.
• W2051227944 cites W2017724964 @default.
• W2051227944 cites W2018520585 @default.
• W2051227944 cites W2019250726 @default.
• W2051227944 cites W2022648619 @default.
• W2051227944 cites W2022875409 @default.
• W2051227944 cites W2024667952 @default.
• W2051227944 cites W2034409892 @default.
• W2051227944 cites W2036547666 @default.
• W2051227944 cites W2041819668 @default.
• W2051227944 cites W2042082964 @default.
• W2051227944 cites W2044804554 @default.
• W2051227944 cites W2048066082 @default.
• W2051227944 cites W2053674548 @default.
• W2051227944 cites W2056610699 @default.
• W2051227944 cites W2073895085 @default.
• W2051227944 cites W2076328665 @default.
• W2051227944 cites W2076675939 @default.
• W2051227944 cites W2080553191 @default.
• W2051227944 cites W2098563021 @default.
• W2051227944 cites W2106108126 @default.
• W2051227944 cites W2106787323 @default.
• W2051227944 cites W2115528176 @default.
• W2051227944 cites W2117298495 @default.
• W2051227944 cites W2124547745 @default.
• W2051227944 cites W2124842132 @default.
• W2051227944 cites W2128946284 @default.
• W2051227944 cites W2133071878 @default.
• W2051227944 cites W2135597217 @default.
• W2051227944 cites W2138771150 @default.
• W2051227944 cites W2144845039 @default.
• W2051227944 cites W2154460209 @default.
• W2051227944 cites W2158318967 @default.
• W2051227944 cites W2162530578 @default.
• W2051227944 cites W2164194457 @default.
• W2051227944 cites W2165172136 @default.
• W2051227944 cites W2169637630 @default.
• W2051227944 cites W2171048459 @default.
• W2051227944 cites W2182816319 @default.
• W2051227944 cites W2187281613 @default.
• W2051227944 cites W2988844429 @default.
• W2051227944 cites W3140879720 @default.
• W2051227944 cites W402737976 @default.
• W2051227944 cites W57693932 @default.
• W2051227944 cites W2068124123 @default.
• W2051227944 doi "https://doi.org/10.3892/mmr.2011.523" @default.
• W2051227944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21725594" @default.
• W2051227944 hasPublicationYear "2011" @default.
• W2051227944 type Work @default.
• W2051227944 sameAs 2051227944 @default.
• W2051227944 citedByCount "15" @default.
• W2051227944 countsByYear W20512279442015 @default.
• W2051227944 countsByYear W20512279442016 @default.
• W2051227944 countsByYear W20512279442017 @default.
• W2051227944 countsByYear W20512279442018 @default.
• W2051227944 countsByYear W20512279442019 @default.
• W2051227944 countsByYear W20512279442020 @default.
• W2051227944 countsByYear W20512279442022 @default.
• W2051227944 countsByYear W20512279442023 @default.
• W2051227944 crossrefType "journal-article" @default.
• W2051227944 hasAuthorship W2051227944A5002172316 @default.
• W2051227944 hasAuthorship W2051227944A5002741156 @default.
• W2051227944 hasAuthorship W2051227944A5028526077 @default.
• W2051227944 hasAuthorship W2051227944A5036354373 @default.
• W2051227944 hasAuthorship W2051227944A5037656636 @default.
• W2051227944 hasAuthorship W2051227944A5057368279 @default.
• W2051227944 hasAuthorship W2051227944A5060808021 @default.
• W2051227944 hasBestOaLocation W20512279441 @default.
• W2051227944 hasConcept C104317684 @default.
• W2051227944 hasConcept C121608353 @default.
• W2051227944 hasConcept C127716648 @default.
• W2051227944 hasConcept C134935766 @default.
• W2051227944 hasConcept C135763542 @default.

• next