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- W2051228224 abstract "Dysfunction of serotonergic neurotransmission has been implicated in the etiopathogenesis of major depression (MDD) and alcohol use disorders (AUD). To compare serotonin function in MDD with co-occurring AUD (MDD/AUD), MDD without co-occurring AUD (MDD only) and healthy controls (HC) we sought to study differences in prolactin responses to fenfluramine administration in patients with MDD/AUD, patients with MDD only and HC. In all, 169 subjects (62 MDD/AUD, 75 MDD only, and 32 HC) were entered into the study. Controlling for gender, prolactin responses were lower in the MDD/AUD group compared to the MDD only or the HC group. Controlling for gender and aggression, prolactin responses in the MDD/AUD group remained significantly lower compared to the HC group but the difference between the MDD/AUD and the MDD only groups disappeared. The difference in prolactin responses between MDD/AUD and MDD only could be attributed to higher aggression scores in the MDD/AUD group compared to the MDD group." @default.
- W2051228224 created "2016-06-24" @default.
- W2051228224 creator A5021174338 @default.
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- W2051228224 creator A5065693607 @default.
- W2051228224 creator A5077815451 @default.
- W2051228224 creator A5079876493 @default.
- W2051228224 date "2008-09-01" @default.
- W2051228224 modified "2023-10-18" @default.
- W2051228224 title "Serotonergic responses in depressed patients with or without a history of alcohol use disorders and healthy controls" @default.
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- W2051228224 doi "https://doi.org/10.1016/j.euroneuro.2008.05.005" @default.
- W2051228224 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3785085" @default.
- W2051228224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18590952" @default.
- W2051228224 hasPublicationYear "2008" @default.
- W2051228224 type Work @default.