FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051228488> ?p ?o ?g. }

• W2051228488 endingPage "682" @default.
• W2051228488 startingPage "672" @default.
• W2051228488 abstract "Sedentarism, also termed physical inactivity, is an independent risk factor for cardiovascular diseases. Mechanisms thought to be involved include insulin resistance, dyslipidemia, hypertension, and increased inflammation. It is unknown whether changes in vascular and endothelial function also contribute to this excess risk. We hypothesized that short-term exposure to inactivity would lead to endothelial dysfunction, arterial stiffening, and increased vascular inflammation.Five healthy subjects (four men and one woman) underwent 5 d of bed rest (BR) to simulate inactivity. Measurements of vascular function (flow-mediated vasodilation to evaluate endothelial function; applanation tonometry to assess arterial resistance), inflammation, and metabolism were made before BR, daily during BR, and 2 d after BR recovery period. Subjects maintained an isocaloric diet throughout.BR led to significant decreases in brachial artery and femoral artery flow-mediated vasodilation (brachial: 11 ± 3% pre-BR versus 9 ± 2% end-BR, P = 0.04; femoral: 4 ± 1% versus 2 ± 1%, P = 0.04). The central augmentation index increased with BR (-4 ± 9% versus 5 ± 11%, P = 0.03). Diastolic blood pressure increased (58 ± 7 mm Hg versus 62 ± 7 mm Hg, P = 0.02), whereas neither systolic blood pressure nor heart rate changed. 15-Hydroxyeicosatetraenoic acid, an arachidonic acid metabolite, increased but the other inflammatory and metabolic biomarkers were unchanged.Our findings show that acute exposure to sedentarism results in decreased endothelial function, arterial stiffening, increased diastolic blood pressure, and an increase in 15-hydroxyeicosatetraenoic acid. We speculate that inactivity promotes a vascular deconditioning state characterized by impaired endothelial function, leading to arterial stiffness and increased arterial tone. Although physiologically significant, the underlying mechanisms and clinical relevance of these findings need to be further explored." @default.
• W2051228488 created "2016-06-24" @default.
• W2051228488 creator A5006127694 @default.
• W2051228488 creator A5016520112 @default.
• W2051228488 creator A5018568623 @default.
• W2051228488 creator A5020184881 @default.
• W2051228488 creator A5038585475 @default.
• W2051228488 creator A5042742058 @default.
• W2051228488 creator A5051761107 @default.
• W2051228488 creator A5062638453 @default.
• W2051228488 creator A5064373375 @default.
• W2051228488 creator A5066730609 @default.
• W2051228488 creator A5072415149 @default.
• W2051228488 date "2014-08-01" @default.
• W2051228488 modified "2023-10-12" @default.
• W2051228488 title "Short-term physical inactivity impairs vascular function" @default.
• W2051228488 cites W1541853979 @default.
• W2051228488 cites W1555489744 @default.
• W2051228488 cites W1557753272 @default.
• W2051228488 cites W1631449371 @default.
• W2051228488 cites W1645045438 @default.
• W2051228488 cites W1922332853 @default.
• W2051228488 cites W1966058811 @default.
• W2051228488 cites W1971474283 @default.
• W2051228488 cites W1984041740 @default.
• W2051228488 cites W1984700685 @default.
• W2051228488 cites W1986212564 @default.
• W2051228488 cites W1996583661 @default.
• W2051228488 cites W1997279776 @default.
• W2051228488 cites W2003076495 @default.
• W2051228488 cites W2004536682 @default.
• W2051228488 cites W2006185943 @default.
• W2051228488 cites W2006909813 @default.
• W2051228488 cites W2008202040 @default.
• W2051228488 cites W2028869149 @default.
• W2051228488 cites W2034937689 @default.
• W2051228488 cites W2043461643 @default.
• W2051228488 cites W2044274972 @default.
• W2051228488 cites W2045643994 @default.
• W2051228488 cites W2046186201 @default.
• W2051228488 cites W2046385949 @default.
• W2051228488 cites W2059265181 @default.
• W2051228488 cites W2059511498 @default.
• W2051228488 cites W2061059440 @default.
• W2051228488 cites W2076633296 @default.
• W2051228488 cites W2078909146 @default.
• W2051228488 cites W2083805707 @default.
• W2051228488 cites W2088639163 @default.
• W2051228488 cites W2097796010 @default.
• W2051228488 cites W2097978321 @default.
• W2051228488 cites W2099221375 @default.
• W2051228488 cites W2100564424 @default.
• W2051228488 cites W2102138771 @default.
• W2051228488 cites W2103921344 @default.
• W2051228488 cites W2108911915 @default.
• W2051228488 cites W2111253176 @default.
• W2051228488 cites W2115693011 @default.
• W2051228488 cites W2118379071 @default.
• W2051228488 cites W2122055987 @default.
• W2051228488 cites W2130284857 @default.
• W2051228488 cites W2131176481 @default.
• W2051228488 cites W2131979392 @default.
• W2051228488 cites W2132464590 @default.
• W2051228488 cites W2135781416 @default.
• W2051228488 cites W2141178160 @default.
• W2051228488 cites W2141665762 @default.
• W2051228488 cites W2143057118 @default.
• W2051228488 cites W2143320440 @default.
• W2051228488 cites W2148637873 @default.
• W2051228488 cites W2153875779 @default.
• W2051228488 cites W2154148361 @default.
• W2051228488 cites W2159094171 @default.
• W2051228488 cites W2160234571 @default.
• W2051228488 cites W2160913962 @default.
• W2051228488 cites W2161841978 @default.
• W2051228488 cites W2166545507 @default.
• W2051228488 cites W2166977140 @default.
• W2051228488 cites W2419064050 @default.
• W2051228488 cites W2731336454 @default.
• W2051228488 cites W4230599757 @default.
• W2051228488 cites W4234756224 @default.
• W2051228488 cites W4241136964 @default.
• W2051228488 cites W4242270851 @default.
• W2051228488 cites W85851589 @default.
• W2051228488 doi "https://doi.org/10.1016/j.jss.2014.02.001" @default.
• W2051228488 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4096607" @default.
• W2051228488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24630521" @default.
• W2051228488 hasPublicationYear "2014" @default.
• W2051228488 type Work @default.
• W2051228488 sameAs 2051228488 @default.
• W2051228488 citedByCount "77" @default.
• W2051228488 countsByYear W20512284882014 @default.
• W2051228488 countsByYear W20512284882015 @default.
• W2051228488 countsByYear W20512284882016 @default.
• W2051228488 countsByYear W20512284882017 @default.
• W2051228488 countsByYear W20512284882018 @default.
• W2051228488 countsByYear W20512284882019 @default.
• W2051228488 countsByYear W20512284882020 @default.

• next