Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051228777> ?p ?o ?g. }
- W2051228777 endingPage "1009" @default.
- W2051228777 startingPage "998" @default.
- W2051228777 abstract "Piscidin 1 (Pis-1) has a high broad-spectrum activity against bacteria, fungi, and viruses but it also has a moderate hemolytic activities. To improve the antibacterial activity and to reduce toxicity, mutants Pis-1AA (G8A/G13A double mutant) and Pis-1PG (G8P mutant) have been designed based on the crystal structure of Pis-1. Eighteen independent molecular dynamics (MD) simulations of Pis-1 and its mutants with membranes are conducted in this article. Furthermore, 60 independent MD simulations of three peptides in water box have also been discussed for comparison. The results indicate that the unfolding process starts at the middle of the peptide. Pis-1 disrupts easily in the region of Val10-Lys14. Pis-1PG has a flexible N-terminal region, and the interaction between N-terminal and C-terminal is very weak. Pis-1AA has the most stable helical structure. In addition, percentage of native contacts and hydrogen bonds analysis are also performed. Lipid-peptide interaction analysis suggests that Pis-1 and Pis-1AA has a stronger interaction with the zwitterionic dioleoylphosphatidylcholine (DOPC) lipid bilayer than Pis-1PG. When compared with the results of peptide with membrane, peptides are unstable and unfolding quickly in water solution. Our results are applicable in examining diversities on hemolytic, antibacterial, and selectivity of antimicrobial peptides. © 2012 Wiley Periodicals, Inc. Biopolymers 97:998–1009, 2012." @default.
- W2051228777 created "2016-06-24" @default.
- W2051228777 creator A5002150542 @default.
- W2051228777 creator A5002661071 @default.
- W2051228777 creator A5010723453 @default.
- W2051228777 creator A5049711880 @default.
- W2051228777 creator A5074109337 @default.
- W2051228777 date "2012-09-17" @default.
- W2051228777 modified "2023-10-05" @default.
- W2051228777 title "Molecular dynamics studies of the antimicrobial peptides piscidin 1 and its mutants with a DOPC lipid bilayer" @default.
- W2051228777 cites W1516030996 @default.
- W2051228777 cites W1627878190 @default.
- W2051228777 cites W1966001866 @default.
- W2051228777 cites W1976301815 @default.
- W2051228777 cites W1978774930 @default.
- W2051228777 cites W1982640141 @default.
- W2051228777 cites W1982664201 @default.
- W2051228777 cites W1989451255 @default.
- W2051228777 cites W1995426501 @default.
- W2051228777 cites W2001797887 @default.
- W2051228777 cites W2002066211 @default.
- W2051228777 cites W2003493354 @default.
- W2051228777 cites W2007691194 @default.
- W2051228777 cites W2008708467 @default.
- W2051228777 cites W2022714443 @default.
- W2051228777 cites W2023100445 @default.
- W2051228777 cites W2029667189 @default.
- W2051228777 cites W2031701155 @default.
- W2051228777 cites W2032284161 @default.
- W2051228777 cites W2035266068 @default.
- W2051228777 cites W2038069317 @default.
- W2051228777 cites W2043666236 @default.
- W2051228777 cites W2046704370 @default.
- W2051228777 cites W2047887742 @default.
- W2051228777 cites W2060306551 @default.
- W2051228777 cites W2061066461 @default.
- W2051228777 cites W2078742168 @default.
- W2051228777 cites W2081090090 @default.
- W2051228777 cites W2082433219 @default.
- W2051228777 cites W2083164919 @default.
- W2051228777 cites W2083183071 @default.
- W2051228777 cites W2084082061 @default.
- W2051228777 cites W2084607551 @default.
- W2051228777 cites W2085136523 @default.
- W2051228777 cites W2089468765 @default.
- W2051228777 cites W2100621506 @default.
- W2051228777 cites W2103302348 @default.
- W2051228777 cites W2103567156 @default.
- W2051228777 cites W2106140689 @default.
- W2051228777 cites W2113403117 @default.
- W2051228777 cites W2147993766 @default.
- W2051228777 cites W2152468191 @default.
- W2051228777 cites W2158482458 @default.
- W2051228777 cites W2170912840 @default.
- W2051228777 doi "https://doi.org/10.1002/bip.22116" @default.
- W2051228777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22987590" @default.
- W2051228777 hasPublicationYear "2012" @default.
- W2051228777 type Work @default.
- W2051228777 sameAs 2051228777 @default.
- W2051228777 citedByCount "12" @default.
- W2051228777 countsByYear W20512287772014 @default.
- W2051228777 countsByYear W20512287772015 @default.
- W2051228777 countsByYear W20512287772016 @default.
- W2051228777 countsByYear W20512287772017 @default.
- W2051228777 countsByYear W20512287772018 @default.
- W2051228777 countsByYear W20512287772020 @default.
- W2051228777 countsByYear W20512287772023 @default.
- W2051228777 crossrefType "journal-article" @default.
- W2051228777 hasAuthorship W2051228777A5002150542 @default.
- W2051228777 hasAuthorship W2051228777A5002661071 @default.
- W2051228777 hasAuthorship W2051228777A5010723453 @default.
- W2051228777 hasAuthorship W2051228777A5049711880 @default.
- W2051228777 hasAuthorship W2051228777A5074109337 @default.
- W2051228777 hasBestOaLocation W20512287771 @default.
- W2051228777 hasConcept C104317684 @default.
- W2051228777 hasConcept C112887158 @default.
- W2051228777 hasConcept C12554922 @default.
- W2051228777 hasConcept C143065580 @default.
- W2051228777 hasConcept C147597530 @default.
- W2051228777 hasConcept C178790620 @default.
- W2051228777 hasConcept C185592680 @default.
- W2051228777 hasConcept C192157962 @default.
- W2051228777 hasConcept C2779281246 @default.
- W2051228777 hasConcept C2780183148 @default.
- W2051228777 hasConcept C32909587 @default.
- W2051228777 hasConcept C39944091 @default.
- W2051228777 hasConcept C41625074 @default.
- W2051228777 hasConcept C540938839 @default.
- W2051228777 hasConcept C553450214 @default.
- W2051228777 hasConcept C55493867 @default.
- W2051228777 hasConcept C59593255 @default.
- W2051228777 hasConcept C86803240 @default.
- W2051228777 hasConceptScore W2051228777C104317684 @default.
- W2051228777 hasConceptScore W2051228777C112887158 @default.
- W2051228777 hasConceptScore W2051228777C12554922 @default.
- W2051228777 hasConceptScore W2051228777C143065580 @default.
- W2051228777 hasConceptScore W2051228777C147597530 @default.
- W2051228777 hasConceptScore W2051228777C178790620 @default.