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- W2051228957 abstract "Abstract The layer‐by‐layer (LbL) assembly technique was applied for the surface modification of biodegradable poly(lactide‐ co ‐glycolide) nanoparticles (NPs), employing poly(acrylic acid) (PAA), and polyethylenimine (PEI) as building blocks. Amino terminated poly(ethylene glycol) (PEG) and folate decorated PEG (PEG‐FA) were grafted onto the multilayers via condensation between carboxylic groups and amine groups from PEG or PEG‐FA. The LbL assembly and the covalent functionalization were monitored by means of ζ ‐potential measurements and the quartz crystal microbalance with dissipation technique (QCM‐D). Protein adsorption after incubation of the NPs in culture medium containing optionally the serum proteins was investigated and related to cellular uptake. Experiments on cellular uptake showed that after PEGylation the uptake ratio of the NPs decreased significantly, but became three times larger when PEG‐FA was grafted on the NPs instead of the PEG. magnified image" @default.
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- W2051228957 date "2010-02-12" @default.
- W2051228957 modified "2023-10-17" @default.
- W2051228957 title "Folic Acid Modified Poly(lactide‐<i>co</i>‐glycolide) Nanoparticles, Layer‐by‐Layer Surface Engineered for Targeted Delivery" @default.
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- W2051228957 doi "https://doi.org/10.1002/macp.200900514" @default.
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