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- W2051229073 abstract "Abstract Huntington's disease (HD) is an autosomal dominant, symptomatically complex neurological disorder which, although normally manifested in the adult years, has been reported at all ages (1). Because of the dominant nature of the disorder, offsprings of an effected individual have a 50% probability of developing the disease at some time in their life. At present it is neither possible to accurately predict which at-risk individuals possess the gene for HD nor is it possible to prevent the onset of the disease or arrest its progress. In the past few years research on HD has yielded significant information about the neuroanatomical and neurochemical deficits present in the disorder. As a result of these studies, it is probable that in the near future more specific and effective pharmacological agents will be developed to help ameliorate the symptoms of this disease. In addition, these investigations have also yielded new insights into the interneuronal relationships which exist in the normal human brain and thus the findings are of fundamental importance in neurobiology. This review is intended to briefly summarize the clinical, neuropathological, neurochemical and pharmacological features of HD with special emphasis on more recent findings. Interested readers are urged to consult other sources for more comprehensive discussions of these topics. (1–3,8)." @default.
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- W2051229073 date "1977-01-01" @default.
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- W2051229073 title "Neurobiology and pharmacology of Huntington's disease" @default.
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- W2051229073 doi "https://doi.org/10.1016/0024-3205(77)90314-9" @default.
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