SemOpenAlex |

SemOpenAlex

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051229190> ?p ?o ?g. }

Showing items 1 to 100 of ±111 with 100 items per page.

W2051229190 endingPage "38" @default.
W2051229190 startingPage "27" @default.
W2051229190 abstract "Liver microsome and hepatocyte-mediated biotransformation of three oral antileishmanial 2-substituted quinolines were investigated. One quinoline contains an n-propyl group (1) and the other a propenyl chain functionalized at the gamma position either by a nitrile (2) or an alcohol (3). The different isoforms of rat cytochrome P450 responsible for biotransformation of 1 were also investigated. Compounds 2 and 3 mainly reacted with glutathione, preventing further metabolism. Compound 3 however, the reaction being reversible, could be released from glutathione and take alternative reaction pathways. Microsomal incubations of 1 mainly led to hydroxylation of the side chain, involving many cytochromes, predominantly CYP2B1, CYP2A6 and CYP1A1 (at more than 80%). In contrary, minor metabolites hydroxylated on the quinoline ring involved a few cytochromes. The hydroxylated products of 1 were conjugated with glucuronic acid in rat hepatocyte incubations." @default.
W2051229190 created "2016-06-24" @default.
W2051229190 creator A5005356850 @default.
W2051229190 creator A5026145335 @default.
W2051229190 creator A5044437310 @default.
W2051229190 creator A5052098655 @default.
W2051229190 creator A5065498868 @default.
W2051229190 creator A5077402497 @default.
W2051229190 creator A5078424632 @default.
W2051229190 date "2007-06-03" @default.
W2051229190 modified "2023-10-18" @default.
W2051229190 title "Metabolism of 2-substituted quinolines with antileishmanial activity studied in vitro with liver microsomes, hepatocytes and recombinantly expressed enzymes analyzed by LC/MS" @default.
W2051229190 cites W1603199091 @default.
W2051229190 cites W1963542761 @default.
W2051229190 cites W1964705652 @default.
W2051229190 cites W1972963629 @default.
W2051229190 cites W1981255635 @default.
W2051229190 cites W1990246438 @default.
W2051229190 cites W2016587111 @default.
W2051229190 cites W2018374802 @default.
W2051229190 cites W2026650883 @default.
W2051229190 cites W2032595657 @default.
W2051229190 cites W2060245731 @default.
W2051229190 cites W2061500389 @default.
W2051229190 cites W2064799851 @default.
W2051229190 cites W2071360084 @default.
W2051229190 cites W2078348254 @default.
W2051229190 cites W2094666011 @default.
W2051229190 cites W2119789069 @default.
W2051229190 cites W2121194231 @default.
W2051229190 cites W2125356967 @default.
W2051229190 cites W2141493842 @default.
W2051229190 cites W2152690666 @default.
W2051229190 cites W2170956456 @default.
W2051229190 cites W205645249 @default.
W2051229190 doi "https://doi.org/10.1016/j.tox.2007.03.003" @default.
W2051229190 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17434249" @default.
W2051229190 hasPublicationYear "2007" @default.
W2051229190 type Work @default.
W2051229190 sameAs 2051229190 @default.
W2051229190 citedByCount "12" @default.
W2051229190 countsByYear W20512291902019 @default.
W2051229190 countsByYear W20512291902020 @default.
W2051229190 countsByYear W20512291902021 @default.
W2051229190 countsByYear W20512291902022 @default.
W2051229190 crossrefType "journal-article" @default.
W2051229190 hasAuthorship W2051229190A5005356850 @default.
W2051229190 hasAuthorship W2051229190A5026145335 @default.
W2051229190 hasAuthorship W2051229190A5044437310 @default.
W2051229190 hasAuthorship W2051229190A5052098655 @default.
W2051229190 hasAuthorship W2051229190A5065498868 @default.
W2051229190 hasAuthorship W2051229190A5077402497 @default.
W2051229190 hasAuthorship W2051229190A5078424632 @default.
W2051229190 hasConcept C100817775 @default.
W2051229190 hasConcept C109650736 @default.
W2051229190 hasConcept C178790620 @default.
W2051229190 hasConcept C181199279 @default.
W2051229190 hasConcept C185592680 @default.
W2051229190 hasConcept C196013638 @default.
W2051229190 hasConcept C202751555 @default.
W2051229190 hasConcept C2776200302 @default.
W2051229190 hasConcept C2776309666 @default.
W2051229190 hasConcept C2776648616 @default.
W2051229190 hasConcept C2781109383 @default.
W2051229190 hasConcept C27881333 @default.
W2051229190 hasConcept C526171541 @default.
W2051229190 hasConcept C538909803 @default.
W2051229190 hasConcept C55493867 @default.
W2051229190 hasConcept C62231903 @default.
W2051229190 hasConcept C71240020 @default.
W2051229190 hasConcept C87644729 @default.
W2051229190 hasConceptScore W2051229190C100817775 @default.
W2051229190 hasConceptScore W2051229190C109650736 @default.
W2051229190 hasConceptScore W2051229190C178790620 @default.
W2051229190 hasConceptScore W2051229190C181199279 @default.
W2051229190 hasConceptScore W2051229190C185592680 @default.
W2051229190 hasConceptScore W2051229190C196013638 @default.
W2051229190 hasConceptScore W2051229190C202751555 @default.
W2051229190 hasConceptScore W2051229190C2776200302 @default.
W2051229190 hasConceptScore W2051229190C2776309666 @default.
W2051229190 hasConceptScore W2051229190C2776648616 @default.
W2051229190 hasConceptScore W2051229190C2781109383 @default.
W2051229190 hasConceptScore W2051229190C27881333 @default.
W2051229190 hasConceptScore W2051229190C526171541 @default.
W2051229190 hasConceptScore W2051229190C538909803 @default.
W2051229190 hasConceptScore W2051229190C55493867 @default.
W2051229190 hasConceptScore W2051229190C62231903 @default.
W2051229190 hasConceptScore W2051229190C71240020 @default.
W2051229190 hasConceptScore W2051229190C87644729 @default.
W2051229190 hasIssue "1-2" @default.
W2051229190 hasLocation W20512291901 @default.
W2051229190 hasLocation W20512291902 @default.
W2051229190 hasOpenAccess W2051229190 @default.
W2051229190 hasPrimaryLocation W20512291901 @default.
W2051229190 hasRelatedWork W1596940606 @default.
W2051229190 hasRelatedWork W1700334471 @default.
W2051229190 hasRelatedWork W2051229190 @default.
W2051229190 hasRelatedWork W2077331899 @default.