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- W2051229259 endingPage "63" @default.
- W2051229259 startingPage "45" @default.
- W2051229259 abstract "Macrophage migration inhibitory factor (MIF) is a pleiotropic proinflammatory cytokine that has been implicated as playing a causative role in many disease states, including sepsis, pneumonia, diabetes, rheumatoid arthritis, inflammatory bowel disease, psoriasis and cancer. To inhibit the enzymatic and biologic activities of MIF, we and others have developed small-molecule MIF inhibitors. Most MIF inhibitors bind within the hydrophobic pocket that contains highly conserved amino acids known to be essential for MIF's proinflammatory activity. The best characterized of these small-molecule MIF inhibitors, (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester (ISO-1) has been validated in scores of laboratories worldwide. Like neutralizing anti-MIF antibodies, ISO-1 significantly improves survival and reduces disease progression and/or severity in multiple murine models where MIF is implicated. This MIF inhibitor, its derivatives and other MIF-targeted compounds show great promise for future testing in disease states where increased MIF activity has been discovered." @default.
- W2051229259 created "2016-06-24" @default.
- W2051229259 creator A5037287374 @default.
- W2051229259 creator A5078561745 @default.
- W2051229259 date "2011-01-01" @default.
- W2051229259 modified "2023-09-24" @default.
- W2051229259 title "MIF as a disease target: ISO-1 as a proof-of-concept therapeutic" @default.
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