FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051229410> ?p ?o ?g. }

• W2051229410 endingPage "1027" @default.
• W2051229410 startingPage "1015" @default.
• W2051229410 abstract "Cellular apoptosis in a tissue may occur for the maintenance of proper ratio of cells or because of toxic effects of free radicals or other agents. Male germ cell apoptosis is pivotal in maintaining the proper functioning of the testis, but it is not clear how free radicals affect germ cells and what the defense mechanisms are that are used by these cells to combat the toxic effects of the products of oxidative stress. This study shows that male germ cells are susceptible to H(2)O(2)-induced stress and, upon exposure to H(2)O(2) in vitro, demonstrate a typical apoptotic phenotype that includes DNA fragmentation and formation of DNA ladders. Other changes include considerable accumulation of products of lipid peroxidation in the germ cells after exposure to H(2)O(2). Evidence is presented for the existence of multiple isoforms of glutathione S-transferases (GSTs) that possess both transferase and Se-independent peroxidase activity. Germ cell GST activity increases after H(2)O(2) exposure. If this increase in activity is inhibited with suitable inhibitors, the formation of products of lipid peroxidation is augmented, resulting in germ cell apoptosis. Also, when constitutive GST activity is inhibited, accumulation of products of lipid peroxidation occurs, resulting in increased cellular apoptosis. These data show that GSTs form a part of adaptive response of germ cells to oxidative stress and are important constituents in detoxifying the products of lipid peroxidation." @default.
• W2051229410 created "2016-06-24" @default.
• W2051229410 creator A5016622802 @default.
• W2051229410 creator A5082812059 @default.
• W2051229410 date "2000-11-01" @default.
• W2051229410 modified "2023-09-27" @default.
• W2051229410 title "Role of glutathione S-transferases in oxidative stress–induced male germ cell apoptosis" @default.
• W2051229410 cites W1614601899 @default.
• W2051229410 cites W1684021943 @default.
• W2051229410 cites W1803300405 @default.
• W2051229410 cites W1879184430 @default.
• W2051229410 cites W1968073601 @default.
• W2051229410 cites W1968677235 @default.
• W2051229410 cites W1968746434 @default.
• W2051229410 cites W1970384337 @default.
• W2051229410 cites W1978973628 @default.
• W2051229410 cites W1981883990 @default.
• W2051229410 cites W1994291765 @default.
• W2051229410 cites W2001639695 @default.
• W2051229410 cites W2003188074 @default.
• W2051229410 cites W2004799228 @default.
• W2051229410 cites W2013812689 @default.
• W2051229410 cites W2016434030 @default.
• W2051229410 cites W2030033338 @default.
• W2051229410 cites W2031473331 @default.
• W2051229410 cites W2038969604 @default.
• W2051229410 cites W2039706098 @default.
• W2051229410 cites W2040958517 @default.
• W2051229410 cites W2046750894 @default.
• W2051229410 cites W2059325180 @default.
• W2051229410 cites W2076795271 @default.
• W2051229410 cites W2079027497 @default.
• W2051229410 cites W2084835105 @default.
• W2051229410 cites W2090691330 @default.
• W2051229410 cites W2100837269 @default.
• W2051229410 cites W2115957878 @default.
• W2051229410 cites W2122765586 @default.
• W2051229410 cites W2129544096 @default.
• W2051229410 cites W2138302361 @default.
• W2051229410 cites W2153235080 @default.
• W2051229410 cites W2170794875 @default.
• W2051229410 cites W2397200553 @default.
• W2051229410 cites W4238354300 @default.
• W2051229410 cites W4246527548 @default.
• W2051229410 cites W4247816627 @default.
• W2051229410 doi "https://doi.org/10.1016/s0891-5849(00)00408-1" @default.
• W2051229410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11084290" @default.
• W2051229410 hasPublicationYear "2000" @default.
• W2051229410 type Work @default.
• W2051229410 sameAs 2051229410 @default.
• W2051229410 citedByCount "123" @default.
• W2051229410 countsByYear W20512294102012 @default.
• W2051229410 countsByYear W20512294102013 @default.
• W2051229410 countsByYear W20512294102014 @default.
• W2051229410 countsByYear W20512294102015 @default.
• W2051229410 countsByYear W20512294102016 @default.
• W2051229410 countsByYear W20512294102017 @default.
• W2051229410 countsByYear W20512294102018 @default.
• W2051229410 countsByYear W20512294102019 @default.
• W2051229410 countsByYear W20512294102020 @default.
• W2051229410 countsByYear W20512294102021 @default.
• W2051229410 countsByYear W20512294102022 @default.
• W2051229410 countsByYear W20512294102023 @default.
• W2051229410 crossrefType "journal-article" @default.
• W2051229410 hasAuthorship W2051229410A5016622802 @default.
• W2051229410 hasAuthorship W2051229410A5082812059 @default.
• W2051229410 hasConcept C104317684 @default.
• W2051229410 hasConcept C143425029 @default.
• W2051229410 hasConcept C181199279 @default.
• W2051229410 hasConcept C185592680 @default.
• W2051229410 hasConcept C18903297 @default.
• W2051229410 hasConcept C190283241 @default.
• W2051229410 hasConcept C191015642 @default.
• W2051229410 hasConcept C2776151105 @default.
• W2051229410 hasConcept C2779122487 @default.
• W2051229410 hasConcept C2780829032 @default.
• W2051229410 hasConcept C31573885 @default.
• W2051229410 hasConcept C43759708 @default.
• W2051229410 hasConcept C538909803 @default.
• W2051229410 hasConcept C552990157 @default.
• W2051229410 hasConcept C55493867 @default.
• W2051229410 hasConcept C86803240 @default.
• W2051229410 hasConcept C95444343 @default.
• W2051229410 hasConceptScore W2051229410C104317684 @default.
• W2051229410 hasConceptScore W2051229410C143425029 @default.
• W2051229410 hasConceptScore W2051229410C181199279 @default.
• W2051229410 hasConceptScore W2051229410C185592680 @default.
• W2051229410 hasConceptScore W2051229410C18903297 @default.
• W2051229410 hasConceptScore W2051229410C190283241 @default.
• W2051229410 hasConceptScore W2051229410C191015642 @default.
• W2051229410 hasConceptScore W2051229410C2776151105 @default.
• W2051229410 hasConceptScore W2051229410C2779122487 @default.
• W2051229410 hasConceptScore W2051229410C2780829032 @default.
• W2051229410 hasConceptScore W2051229410C31573885 @default.
• W2051229410 hasConceptScore W2051229410C43759708 @default.
• W2051229410 hasConceptScore W2051229410C538909803 @default.
• W2051229410 hasConceptScore W2051229410C552990157 @default.
• W2051229410 hasConceptScore W2051229410C55493867 @default.

• next