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• W2051229526 abstract "Abstract A series of anionic liposaccharide derivatives were synthesized in order to develop a system, which would have the capacity to act as an absorption enhancer and to improve oral bioavailability of drugs. The addition of a liposaccharide to a drug enhances drug stability against enzymatic degradation, while the lipophilicity can be controlled by variation of the lipid side chain. All liposaccharide derivatives were purified and fully characterized by nuclear magnetic resonance and high-resolution mass spectrometry. The thermodynamic profiles, critical aggregation concentrations and size of the synthesized liposaccharides were determined by isothermal titration microcalorimetry, transmission electron microscopy and dynamic light scattering. These liposaccharides formed nanoparticles with sizes below 100 nm." @default.
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• W2051229526 date "2012-06-01" @default.
• W2051229526 modified "2023-09-26" @default.
• W2051229526 title "Liposaccharide-based nanoparticulate drug delivery system" @default.
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• W2051229526 doi "https://doi.org/10.1016/j.tet.2012.04.064" @default.
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