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- W2051230648 abstract "Dose-painting radiotherapy allows for a heterogeneous delivery of radiation within the tumour volume by targeting radioresistant areas defined by functional imaging. Within gross tumour volume, it is possible to define one or more target volumes based on biology (biological target volume [BTV]) and to apply a strategy of intensity modulated radiation therapy (IMRT) that will deliver a higher dose to these regions. In this review of the literature, we will highlight the biological elements responsible for radioresistance, and how to image them, then we will detail the radiotherapy techniques necessary for this approach, before presenting clinical results in various situations (head and neck tumours, prostate, brain tumours, etc.). Despite many difficulties that make dose-painting IMRT unusable in routine nowadays, biology-guided radiation therapy represents one of the major pathways of development of radiotherapy in the coming years." @default.
- W2051230648 created "2016-06-24" @default.
- W2051230648 creator A5016598882 @default.
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- W2051230648 creator A5042347658 @default.
- W2051230648 creator A5062513412 @default.
- W2051230648 creator A5090570082 @default.
- W2051230648 date "2010-10-01" @default.
- W2051230648 modified "2023-10-07" @default.
- W2051230648 title "« Dose-painting » : mythe ou réalité ?" @default.
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- W2051230648 doi "https://doi.org/10.1016/j.canrad.2010.06.005" @default.
- W2051230648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20729116" @default.
- W2051230648 hasPublicationYear "2010" @default.
- W2051230648 type Work @default.