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• W2051233933 abstract "Interferon regulatory factor-1 (IRF-1) gene expression is rapidly upregulated in the prolactin (PRL)-activated Nb2 rat T lymphoma cell line. To further elucidate its role as a T cell activation molecule, IRF-1 gene expression in response to various T cell stimuli was examined. In Nb2 T cells, PRL induced two peaks of IRF-1 gene expression: a rapid, transient peak at 1 h and a sustained peak at 12 h. PRL subsequently induced interferon-γ (IFN-γ) gene expression at 3–6 h. However, the early induction of IRF-1 and IFN-γ does not appear to be interdependent. Interleukin-2 (IL-2) also induced IRF-1 gene expression in Nb2 T cells but only one broad peak at 10 h was observed. In primary mouse splenocytes, concanavalin A induced rapid and transient expression of the IRF-1 gene; maximal expression occurred by 6 h, and then returned to basal levels by 12–15 h. These results provide additional evidence for the importance of IRF-1 in T cell activation." @default.
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• W2051233933 date "1992-07-01" @default.
• W2051233933 modified "2023-10-14" @default.
• W2051233933 title "Interferon regulatory factor-1 is inducible by prolactin, interleukin-2 and concanavalin A in T cells" @default.
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• W2051233933 doi "https://doi.org/10.1016/0303-7207(92)90180-e" @default.
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